EVALUATION OF A PANEL OF IHC MARKERS IN DIFFERENTIATION OF EXTRANODAL MALIGNANT SMALL ROUND CELL TUMORS.
Journal Title: International Journal of Advanced Research (IJAR) - Year 2019, Vol 7, Issue 1
Abstract
Background: The small round cell tumors are a heterogeneous group of malignant neoplasms. Immunohistochemistry (IHC) has proven to be a significant tool in the identification as well as differentiation of tumors which become a diagnostic challenge on the basis of routine haematoxylin and eosin (H & E) stain alone. The aim of present study was to study the histomorphological spectrum of extranodal malignant small round cell tumors and to study the significance of a primary panel (LCA, CK, S-100 and Vimentin) and secondary panel of IHC markers in differential diagnosis of such tumors. Methods: The study was carried out in the Department of Pathology, Pt. B.D. Sharma, UHS, Rohtak. A total of 60 cases of malignant small round cell tumors were selected for IHC and they were classified and categorized accordingly after IHC. Results: Out of the 60 cases of malignant small round cell tumors, there were 19 cases (31.6%) of small cell carcinoma, 16 cases (26.6%) of non Hodgkin lymphoma, 5 cases (8.3%) each of Ewing?s sarcoma and PNET, 4 cases (6.7%) of medulloblastoma, 3 cases (5%) each of rhabdomyosarcoma and seminoma and 1 case (1.7%) each of mesothelioma, neuroblastoma, small cell osteosarcoma, Wilm?stumor and poorly differentiated round cell tumor. Conclusion: Immunohistochemistry has played a valuable adjunctive role for routine hematoxylin and eosin staining in the adequate and accurate categorization of small round cell tumors.
Authors and Affiliations
Deepshikha a, Meenu Gill, Gaurav Sharma, Sumiti Gupta, Promil Jain, Veena Gupta, Rajeev Sen.
Keywords
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- EP ID EP460469
- DOI 10.21474/IJAR01/8400
- Views 59
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