EVALUATION OF ALPHA-AMYLASE INHIBITORY ACTIVITY OF GREWIA ABUTILIFOLIA LEAVES
Journal Title: European Journal of Pharmaceutical and Medical Research - Year 2017, Vol 4, Issue 11
Abstract
Alpha-amylase inhibitors are oral anti-diabetic drugs used for diabetes mellitus type 2 that work by preventing the digestion of carbohydrates (such as starch and table sugar).Inhibition of Alpha-amylase enzyme that plays a role in digestion of starch and glycogen is considered a strategy for the treatment of disorders in carbohydrate uptake such as diabetes and obesity.Plants are an important source of chemical constituents with potential for inhibition of Alpha-amylase and can be used as therapeutic or functional food sources. Grewia abutilifolia belonging to the family Tiliaceae,is a tree and that is used in traditional medicine for the treatment of diabetic mellitus. In the present study, methanolic extracts of Grewia abutilifolia leaves which are used in the Ayurvedic traditional system of medicine to treat diabetes were tested for their inhibitory effect on α-amylase. The crude methanol extracts (6.88 ± 0.14) of Greiwa abutilifilia with pet-ether fraction, (21.13 ± 25.24), chloroform fraction(6.02 ± 1.15) and methanol+water fraction (5.2± 0.80). Among all fractions acarbose & methanol+water showed highest percentage inhibition & the Ic50 value was 5.7 ± 0.24 & 5.2 ± 0.80. So, methanol + water extracts has the highest percentage of inhibition than acarbose. As a results, Grewia abutilifolia leaves properly inhibits the alpha-amylase in diabetes.
Authors and Affiliations
Abdullah- Al-Mamun
Keywords
Related Articles
- EP ID EP631069
- DOI -
- Views 161
- Downloads 0
THE EFFICACY OF CUTTING SETON IN TREATMENT OF HIGH ANAL FISTULA
Background: Fistula in- ano is a common conditions that facing thousands of patients. Different surgical methods are used for treatment of high anal fistula. The best surgical option of treatment is variable because they...
NEUROCYSTICERCOSIS AS A PRESENTING FEATURE OF PICA: A CASE REPORT
Neurocysticercosis (NCC) is a zoonotic disease caused by the larval form of the cestode Taenia solium. It is the commonest parasitic infection of the Central nervous system. NCC has a worldwide distribution and is mainly...
AN ASSESSMENT OF QUALITY OF LIFE IN LIBYAN PATIENTS UNDERGOING HEMODIALYSIS
Background: In patients with end-stage renal disease, the need for renal replacement therapy to prolong life represents the final stage of living. Quality of life is one of the concepts that was accepted as a criterion f...
SYSTEMIC LUPUS ERYTHEMATOSUS COMPLICATED BY ISCHAEMIC STROKE AND DEEP VEIN THROMBOSIS IN A NIGERIAN LADY
Background: Systemic lupus erythematosus (SLE) is an autoimmune disease with varied presentation associated with increased morbidity and mortality in those affected. Also, SLE is associated with higher risks of strokes a...
DRUG UTILIZATION EVALUATION OF LOW MOLECULAR WEIGHT HEPARIN IN A TERITARY CARE TEACHING HOSPITAL
Low molecular weight heparins (LMWH) have achieved poly therapeutic drug status and additional indications for their use. Therefore, it is necessary to evaluate the usage of LMWHs in the hospital settings. The main objec...