Evaluation of Amiodarone for Its Effect on Glucose Metabolism in Euglycemic Albino Wistar Rats
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 0, Vol 8, Issue 3
Abstract
Objective: To evaluate the effect of amiodarone on glucose levels in albino wistar rats. Materials and Methods: Albino wistar rats were divided in to test group (amiodarone) and control group (distilled water) of six animals each. They were given test drug i.e amiodarone 180mg/kg and distilled water 5ml/ rat respectively for a period of 5 days. On 5th day OGTT (slightly modified) was performed and cbg values were recorded at 0 min, 60min and 150 min respectively. Results and Discussion: The cbg values were significantly higher (p<0.05) in test group at all the time intervals thereby indicating that amiodarone has hyperglycemic activity in the albino wistar rats. Conclusion: Further studies are required to evaluate the effect of amiodarone in humans and it should be used with caution in diabetics patients.
Authors and Affiliations
Mohammed Sibgatullah , Suresha R. N
Keywords
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