EVALUATION OF ANALGESIC ACTIVITY OF METHANOLIC EXTRACT OF HOLARRHENA ANTIDYSENTERICA LEAVES BY TAIL IMMERSION AND HOT PLATE ASSAY METHODS
Journal Title: World Journal of Pharmaceutical Research - Year 2018, Vol 7, Issue 1
Abstract
Objective: The alcoholic extracts of seeds and barks of Holarrhena antidysenterica have been reported to show antidysenteric, antibacterial, astringent, anthelmintic, stomachic and febrifugal properties. We aimed to evaluate analgesic potential of this plant using methanolic extract of leaf. Methods: In the present study, methanolic extract of Holarrhena antidysenterica leaves was obtained by maceration. Then, analgesic activity of the extract was investigated in mice at three different doses of 100, 200 & 300 mg/kg by using the conventional tail immersion and hot plate assays. Results: In the tail immersion assay, significant analgesia was shown by all doses at 30 & 60 min study period which was comparable to the reference standard (P<0.01). Similar to this, in hot plate assay basal latency times of response were significantly increased by all doses at 30 min study period. However, all doses showed gradual decrease in analgesia after 90 min in both tests. These results demonstrate possible indication of the medicinal use of the leaves of this plant along with mostly reported seeds and barks parts. Conclusion: The methanolic extract of leaves possess significant analgesic potential.
Authors and Affiliations
Prof. Dr. Mohammed Rahmatullah
Keywords
Related Articles
- EP ID EP618616
- DOI -
- Views 151
- Downloads 0
LIGAND BASE PHARMACOPHORE MODELING VRTUAL SCREENING AND DOCKING AGAINST TGFRB1 GENE MUTATION IN BREAST CANCER.
Introduction: The term “breast cancer” refers to a malignant tumor that has developed from cells in the breast. The types of cells that most commonly give rise to breast cancers are the milk-secreting cells and duct cell...
A NEW MEASUREMENT SCALE FOR EVALUATING HEALTHRELATED QUALITY OF LIFE IN PATIENTS WITH POST STROKE IN AL NAJAF AL ASHRAF GOVERNORATE IN IRAQ
Objectives: This study amid to identify and study most properties of the specific and general health-related quality-of-life (HRQoL) in patients with post stroke, and to find out relationships among distribution of an ov...
AN EXPERIMENTAL STUDY OF THE TOXICITY EFFECTS OF CALOTROPIS PROCERA (AITON) ASCLEPIADACEAE IN SPRAGUE-DAWLEY RATS
Calotropis procera Aiton (Calotropis) is a wild-growing plant used for a variety of disease conditions such as leprosy, ulcers, tumor and healing of wounds. The present study was conceived to evaluate the toxicological e...
A REVIEW ON BECKWITH WIEDEMANN SYNDROME
Beckwith-Wiedemann syndrome (BWS) is a disorder involving overgrowth conditions. It is also characterized by a broad spectrum of symptoms and physical conditions that changes in range and severity from person to person....
CHARACTERIZATION OF A NOVEL TAYLOR-COUETTE ULTRAVIOLET REACTOR FOR NON-THERMAL PASTEURIZATION OF MILK
Disinfection of milk by a novel UV reactor based on Taylor-Couette vortex flow has been evaluated as part of an effort to develop nonthermal processing technology for pasteurizing milk. By using Bacillus subtilis endospo...