EVALUATION OF ANTI-ANXIETY ACTIVITY OF ACTAEA SPICATA LINN.
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2011, Vol 3, Issue 1
Abstract
Actaea spicata Linn. (Ranunculaceae) has been traditionally used for the treatment of various ailments such as rheumatism, inflammation, nerve diseases, lumbago, scrofula and chorea. Despite a long tradition of use, no systematic phytochemical and pharmacological work has been carried out on this potential plant. Thus, A. spicata was subjected to preliminary anti-anxiety screening studies, with a view to ascertain the verity of its traditional use as an anxiolytic. In the present investigation, roots of the plant were extracted using solvents in order of increasing polarity viz., petroleum ether (60-80C), chloroform, methanol and distilled water. All the crude extracts were evaluated for anti-anxiety activity in mice using elevated plus maze apparatus. Among all these extracts, only methanol extract exhibited significant anti-anxiety activity at a dose of 100 mg/kg in mice with respect to control as well as standard (diazepam, 2 mg/kg). Phytochemical screening showed presence of alkaloids and polyphenols in methanol extract of A. spicata. Thus, Specific methods were adopted to extract total alkaloidal and polyphenol fractions from the plant material and methanol extract of plant, respectively. Polyphenol fraction exhibited significant anxiolytic activity at the dose of 50 mg/kg, while alkaloidal fraction was found to be devoid of any activity.
Authors and Affiliations
Reecha Madaan, Anupam Sharma
Keywords
Related Articles
- EP ID EP624989
- DOI -
- Views 64
- Downloads 0
METERED DOSE INHALATION FORMULATIONS OF SALBUTAMOL SULPHATE USING NON-CFC PROPELLANT TETRAFLUOROETHANE
Salbutamol sulphate metered dose inhaler formulations were developed with chlorine free, non-CFC propellant Tetrafluoroethane. Suspension formulations were prepared with 4 mg of oleic acid as the surfactant and varying p...
SYNTHESIS AND EVALUATION OF ANTIOXIDANT ACTIVITY OF SEMICARBAZONE DERIVATIVES
In present study, a series of chalconesemicarbazones was synthesized and evaluated for antioxidant activity by DPPH free radical scavenging assay. Most of the compounds were found to be potent antioxidant. Free radicals...
FORMULATION AND IN VITRO EVALUATION OF PIROXICAM EMULGEL
The present work is concerned with the formulation and evaluation of Piroxicam emulgel employing carbopol 934 and xanthan gum as polymers. The emulgel is prepared by combining the gel and emulsion. The gel in formulation...
EVALUATION OF IN-VIVO ANTITUMOR ACTIVITY OF ANNONA CRASSIFLORA WOOD EXTRACT
Annona crassiflora is a native tree from Brazilian savanna area of the state of Minas Gerais. The ethanolic extract of A. crassiflora wood was obtained and purified, and an annonaceous acetogenins-rich fraction was obtai...
NOVEL SYNTHESIS AND ANTIMICROBIAL ACTIVITIES OF THIAZINO-OXAZINE DERIVATIVES
In the designing and synthesis of new heterocyclic compounds, containing two different pharmacophores, we have carried out new series of 3-(4-chlorophenyl)-4-methylidene-4,8-dihydro-2H,5H-1,3-thiazino[5,4-e]-1,3-oxazine-...