EVALUATION OF ANTI-HYPERTROPHIC POTENTIAL OF PIPER BETLE IN ISOPROTERENOL-INDUCED CARDIAC HYPERTROPHIC RAT MODELS
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 7
Abstract
Objective: The objective of this study was to evaluate the anti-hypertrophic potential of the combination extract (chloroform, methanol, and ethyl acetate) of Piper betle in cardiac hypertrophic rat models. Methods: Isoproterenol (ISO) (10 mg/kg b. w., i.p., 7 days) was used to induce cardiac hypertrophy in male albino Wistar rats and simultaneously treated with the combination extract of P. betle (50 mg/kg b. w., oral, 7 days) and the standard drug losartan (50 mg/kg b. w., oral, 7 days) as reference. At the end of seventh day the biochemical estimations of glucose, protein, cholesterol, triglycerides, cardiac marker enzymes (SGOT, SGPT and LDH) and enzymic antioxidants (superoxide dismutase, catalase and glutathione peroxidase) were performed in the serum along with the targets of the study namely calcium and phosphorus. Heart tissues were subjected to histopathological analysis. All biochemical assays were statistically verified. Results: The status of cardiac hypertrophy was indicated by the increased heart weight (HW)/body weight (BW) ratio. The biochemical assays showed significant (p<0.05) increase in the levels of glucose, protein, and cholesterol and in the cardiac marker enzymes such as SGOT, SGPT, and LDH, whereas significant decrease in the serum calcium and phosphorus along with antioxidants were seen in the ISO-induced rats and these levels were restored to normal values by the treatment with P. betle. Conclusion: The combination extract of P. betle showed effect upon calcium and phosphorus levels besides reversing the other impacts of isoproterenol (β-adrenergic hypersignaling events) probably due to phytoconstituents of the plant which are hypothesized to be efficiently extracted in combination of organic solvents, and thus, these results indicate that the combination extract of P. betle possesses cardioprotective (anti-hypertrophic) effect.
Authors and Affiliations
DOSS VA , MANJU VIDHYA SAKTHIKUMAR , DHARANIYAMBIGAI KUBERAPANDIAN
Keywords
Related Articles
- EP ID EP635678
- DOI -
- Views 133
- Downloads 0
CHARACTERIZATION OF MONOHEADED TRYPSIN INHIBITORS FROM THE SEEDS OF ABELMOSCHUS MOSCHATUS L.
Objective: The objective of the present study was to characterize the monoheaded trypsin inhibitors, Abelmoschus moschatus trypsin inhibitor-I (AMTI-I) and AMTI-II from the seeds of A. moschatus with respect to their spe...
IN VITRO CYTOTOXIC ANTICANCER POTENTIAL OF BIOACTIVE FRACTION ISOLATED FROM INDONESIAN TIDAL SPONGE CALTHROPELLA SP.
Objective: This study was taken to examine the cytotoxicity of the bioactive fraction isolated from marine sponge Calthropella sp. as a preliminary anticancer assay and identify its bioactive compounds.Methods: The cytot...
ANATOMICAL STUDIES OF THE FRUIT OF ZIZIPHUS RUGOSA
Objective: The objective of this study was to study the anatomical features of the fruit Ziziphus rugosa. Methods: Surface view, longitudinal, transverse section (T.S), and powder microscopy of the fruits were studied....
ANTIATHEROSCLEROTIC AND ANTIOXIDANT POTENTIAL OF PETROLEUM ETHER EXTRACT OF PROSOPIS CINERARIA POD IN HYPERCHOLESTEROLEMIC RABBITS
Objective: The present study is done to investigate the anti-atherosclerotic efficacy of petroleum ether extract of Prosopis cineraria pod in hypercholesterolemic diet-induced atherosclerosis in rabbits. Methods: Athero...
BIOACTIVITY SCREENING OF SELECTED TRADITIONAL MEDICINAL PLANTS OF KERALA
Objectives: Traditional medicines all over the world is revaluing nowadays by extensive research programs. To validate the traditional use, the active components in them need to be identified, characterized, and biologic...