Evaluation of anti-oxidant and oxidative stress parameters in chronic obstructive pulmonary disease
Journal Title: International Journal of Clinical Biochemistry and Research - Year 2018, Vol 5, Issue 1
Abstract
Introduction: Chronic obstructive pulmonary disease (COPD) is an important lung disorder. Tobacco smoking accounts for 80% of patients of COPD cases and the remaining 20% are due to exposure to environmental tobacco smoke, occupational dusts and chemicals, and indoor air pollution from biomass fuel used for cooking and heating in poorly ventilated buildings. The oxidative stress seen with COPD patients is due to the oxidants present in cigarette smoke and from increased amounts of reactive oxygen species released from leucocytes, from both in air spaces and blood. Materials and Methods: This was prospective, case-control study conducted at a tertiary care teaching hospital (medicine department) from April 2015 to August 2015. After obtaining written informed consent a total of 84 participants were explained about the study. The anti-oxidant parameters i.e. Vitamin C and E, superoxide dismutase, whole blood reduced glutathione and oxidative stress markers i.e. malondialdehyde, serum nitric oxide were measured both in COPD patients and controls. The study was approved by institutional ethics committee. The results are expressed as mean and standard deviation of the parameters evaluated. The unpaired ‘t’ test wass used for comparing different biochemical parameters between cases and controls. The p value of < 0> Results & Discussion: There was no statistically significant difference in the demographic data between the cases and controls. Maximum patients were in stage 3 COPD. Tobacco smoking is an important cause for development of COPD by formation of reactive oxygen species and other free radicals There was statistically significant difference (p<0> Conclusion: The results of the present study indicate a disturbance in oxidant/antioxidant status in COPD patients. The periodic measurements of oxidative stress markers and antioxidant status in COPD patients might be useful in prognosis of the disease. These results may contribute for the development of novel therapeutic interventions.
Authors and Affiliations
Pampareddy B Kollur, Kiran Kumar Akka, Basawarajeshwari P Kollur, Sangappa Virupaxappa Kashinakunti
Keywords
Related Articles
- EP ID EP472040
- DOI 10.18231/2394-6377.2018.0003
- Views 59
- Downloads 0
Association of 25 OH-Vitamin D and hs-CRPin adults with Essential Hypertension
Essential hypertensionis a typical example of complex, multifactorial trait and a well studied risk factor for cardiovascular disease. hs-CRP is well known marker of inflammation resulting in atherosclerosis and cardiova...
C-Peptide and insulin levels in patients of metabolic syndrome
Metabolic Syndrome (MetS) is cluster of physical conditions and metabolic abnormalities commonly found in association with increased risk for development of type-2 diabetes mellitus (T2DM), cardiovascular disease (CVD)...
Mathematical model of evaluation of Insulin Resistance using Homeostasis Model Assessment – Insulin Resistance Index in patients with Hyperthyroidism
Aim: To evaluate insulin resistance using HOMA-IR index in patients with overt and subclinical hyperthyroidism. Materials and Method: A randomized case control study on female population was conducted. For which 30 overt...
Evaluation of serum albumin as a prognostic marker in traumatic brain injury
Introduction: Traumatic Brain Injury (TBI) due to road traffic accidents is one of the leading causes of mortality and morbidity in India. Since albumin is associated with the patho-physiological events following TBI, we...
Effectiveness of computerized ordering of test using unique hospital identification number to reduce pre analytical errors - a cross sectional study in a tertiary care hospital of south India
Introduction Laboratory test request forms are important communication device between the clinician and lab personnel Studies have confirmed that most laboratory errors occur in the preanalytical phase clinicians are ord...