Evaluation of Anticandidal Effects of Allium saralicum
Journal Title: مجله علمی- پژوهشی دانشگاه علوم پزشکی قم - Year 2017, Vol 11, Issue 6
Abstract
Background and Objectives: Candida species is one of the main fungal pathogens in immunodeficient, organ transplantation, and cancer patients. Resistance to antifungal therapy, is observed in candida species, such as Candida albicans, Candida glabrata, and Candida tropicalis. For this purpose, screening of the medicinal plants and investigation of their antifungal effect is necessary. This study was conducted with the aim of in vitro evaluation of inhibitory effect of Allium saralicum on candida species. Methods: In this descriptive-comparative study, Allium saralicum plant was collected from Shahoo mountain in Kermanshah, and extracted using soxhlet apparatus. Antifungal activity of methanol and petroleum ether extracts, were investigated against C. albicans, C. glabrata and C. tropicalis. Well diffusion method was used as a screening method, and minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC), were determined. Results were analyzed by nonparametric Kruskal-Wallis and Mann-Whitney tests. Results: In this research, the highest inhibition zone of Allium saralicum extracts against all species, was observed in concentration of 250mg/ml, and inhibition zone diameter decreased with decrease in concentration. MIC and MFC results showed that C. albicans is more sensitive to the petroleum ether extract, while C. tropicalis growth was significantly inhibited by the methanol extract. The results of both extracts was equal for C. glabrata. Conclusion: According to the results of this research, methanol and petroleum ether extracts of Allium saralicum have antifungal activity against Candida species. Therefore, this plant can be used as a natural antimicrobial source.
Authors and Affiliations
Faranak Faranak, Mahboobeh Mahboobeh, Mohammad Mohammad
اثرات ایمونولوژیکی نانوذرات کیتوزان بر سلولهای سرطانی سینه در مدل حیوانی
زمینه و هدف: سرطان از علل عمده مرگ و میر در سراسر جهان است. درمانهای دارویی، متعارف با استفاده از داروهای سیتوتوکسیک دارای سطح بالایی از عوارض جانبی برای بیمار هستند. کیتوزان یک ترکیب زیست سازگار و زیست تخریبپذیر میبا...
تأثیر برنامه تمرین ترکیبی و مکمل یاری فروگلوبین بر آهن سرم و پروفایللیپیدی زنان مبتلا به آنمی فقر آهن
زمینه و هدف: آهن میتواند نقش مهمی در عملکرد ورزشی زنان ایفا کند. هدف پژوهش حاضر، بررسی و تعیین آثار برنامه تمرین ترکیبی و مکملیاری فروگلوبین بر آهن سرم و پروفایللیپیدی زنان مبتلا به آنمی فقر آهن بود. روش بررسی: در این...
Evaluation of Simultaneous Exposure to Flour Dust and Airborne Fungal Spores in Milling Plant
Background and Objectives: Wheat flour as an organic allergen particle has an extensive respiratory exposure in milling industry and related industries. Simultaneous exposure to flour dust and fungal spores causes infect...
شیوع ژنهای کدکننده پمپهای ترشحی qep Aو acrAB در سویههای کلبسیلا پنومونیه، جداشده از بیماران بستری در بیمارستانهای منتخب شهر تهران
زمینه و هدف: افزایش ظهور مقاومت فلوروکینولونی بین سویههای بالینی کلبسیلا پنومونیه، گزینههای درمانی عفونتهای ناشی از این باکتریها را کاهش داده است. این مطالعه با هدف بررسی شیوع ژنهای کدکننده پمپهای ترشحی qepA و acrA...
Investigation of the Association between GFPT2 Gene Polymorphism and Risk of Type 2 Diabetes
Background and Objectives: Type 2 diabetes is one of the most common metabolic diseases and a complex disorder with a strong genetic predisposition, which significantly affects mortality. A series of factors, such as env...