Evaluation of Anticoagulant Proteins and Fibrinolytic System Markers in Children with Pneumonia
Journal Title: The Journal of Pediatric Research - Year 2019, Vol 6, Issue 1
Abstract
Aim: Coagulation and fibrinolytic systems play an important role in the pathogenesis of complicated pneumonia. This study aims to evaluate and compare coagulation and fibrinolytic system markers and natural anticoagulant proteins with acute phase reactants, such as C-reactive protein or procalcitonin in children with pneumonia. Materials and Methods: One hundred and fifteen patients and 87 healthy children were included in the study. Patients were separated into two groups based on viral and bacterial pneumonia diagnosis. Coagulation and anticoagulation system markers were compared with acute phase reactants in children with pneumonia. Results: White blood cell numbers and D-dimer (DD) levels were higher in the pneumonia patients compared to the control group (p=0.001 and 0.001 respectively). Protein C activity and antithrombin activity in the patient group were significantly lower compared to the control group (p=0.001 and p=0.011 respectively). Acute phase reactants and DD levels in the bacterial pneumonia patients were higher compared to the viral pneumonia patients (p<0.05). Protein S activity, fibrin monomers and fibrin degradation products were not significantly different between the bacterial and viral pneumonia patients. Protein S activity in the bacterial pneumonia patients was lower compared to the viral pneumonia patients (p=0.040). There was no difference in terms of antithrombin activity and protein C activity. Conclusion: As a result, the relationships among acute phase proteins, anticoagulation proteins, and fibrinolytic system markers show that the coagulation and fibrinolytic system has an important role in pneumonia pathogenesis and associated inflammation. Evaluation of the coagulation system may help determine the severity of pneumonia in children and be used to monitor its clinical progress.
Authors and Affiliations
Zahide Yalaki, Bülent Alioğlu, Nurdan Çiftçi, Fatma İnci Arıkan
Keywords
Related Articles
- EP ID EP549478
- DOI 10.4274/jpr.galenos.2018.32448
- Views 93
- Downloads 0
Practical Aspects of the Use of Healthcare Failure Mode and Effects Analysis Tool in The Risk Management of Pediatric Emergency Department: The Scrutiny in Iran
Aim: The Emergency Department is one of the most challenging wards of the hospital for studying patient safety and the prevention of treatment errors is the basic rule in the quality of health care. The present study was...
The Results of the Treatment of Osteogenesis Imperfecta with Corkscrew Tipped Telescopic Nail
Aim: We aimed to evaluate the clinical and radiological results of an intramedullary fixation system used in surgeries for fractures and deformities of osteogenesis imperfecta where we applied a new design corkscrew tipp...
National Newborn Screening Tests Carried Out with Heel Lance and Their Importance
Inbreeding is very common in our country, and this brings along various congenital metabolic diseases. In order to detect the congenital metabolic diseases at an early stage, lots of screening tests are carried out on th...
Platelet Indices and the Severity of Dengue Infection in Children
Aim: Dengue is becoming endemic in India. The reported case-fatality rate in India is 3-5%. Thrombocytopenia is the most common finding. Platelet indices are gaining importance in the illness. To study the platelet indic...
A Rare Cause of Diplopia: Idiopathic Orbital Myositis
Orbital myositis is an entity affecting the ocular muscles, especially the medial rectus. These cases are usually referred to clinics with complaints such as diplopia, orbital/periorbital pain, limitation in ocular movem...