Evaluation of Antimicrobial, Antifungal, and Cytotoxic Properties of Abroma augusta Linn.
Journal Title: Asian Journal of Chemical Sciences - Year 2017, Vol 3, Issue 2
Abstract
Objective: This present study has been undertaken to evaluate the antimicrobial, antifungal and cytotoxic properties of four different fractionates such as petroleum ether, chloroform, ethyl acetate and dia-ion resin adsorbed fractions of Abroma augusta leaf extract. Methodology: The antimicrobial and antifungal properties have been characterized by disc diffusion method. The cytotoxicity property was determined against brine shrimp nauplii. Results and Conclusion: Among the four fractionates, the dia-ion resin adsorbed fraction showed the highest activity towards the S. aureus, E. coli bacteria and the fungus C. albicans with the zone inhibition of 1213 mm which was comparable with that of the standard Kanamycin. The chloroform, petroleum ether, and ethyl acetate fraction was exhibited least activity toward the bacteria and fungus with the zone inhibition of 69 mm. Similarly, the dia-ion resin adsorbed fractions showed the highest antifungal activity with the zone inhibition of 15 mm. From the results of cytotoxicity test, it was observed that the chloroform and ethyl acetate fractions were found be the highest active on 6, 12, 18, 24, and 30h of exposures in which almost all the nauplii were dead. From the corresponding LD50 values, the chloroform and ethyl acetate fractions were found to be the highest toxic against Artemia salina nauplii of 75.019 and 65.553 ppm, respectively. It has been predicted that the Abroma augusta leaves might be considered as a potent cytotoxic agent for further advanced research.
Authors and Affiliations
Md. Abdul Mannan, Zahidul Islam, Md. Jakir Hossen, A. B. M. Hamidul Haque, Md. Kudrat E-Zahan, Shahed Zaman, Debashish Talukder
Keywords
Related Articles
- EP ID EP338854
- DOI 10.9734/AJOCS/2017/35638
- Views 130
- Downloads 0
Phytochemical Composition and Evaluation of Antimicrobial Activity of Blepharis linariifolia (Pers.) Seeds
Blepharis linariifolia (Pers.) originates from Sudan and grows widely in Africa. The current study has been designed to evaluate the bioactive compounds and antimicrobial activity of the n-hexane extract of Blepharis lin...
Treatments of Recycled Pulps from Old Corrugated Containers. Part II. The Effects of Boron Compounds on Strength Properties
The paper from secondary fibers has generally considered to be used in corrugated cardboard production. For this purpose, Sack Corrugated Test (SCT) and Corrugated Medium Tests were used to determine the strength resista...
Phytochemical Screening and Antibacterial Activity of Spondias mombin Leaves
Phytochemical investigation was carried out on the crude ethanol extracts of the leaves of Spondias mombin. The antibacterial activity of the ethanolic and the Chloroform leaf extract was tested against four bacteria; Es...
Optical Absorbance and Band Structure of Molecular Hydrogen in Different Phases
In this article, optical absorbtion and band structure of solid molecular hydrogen at five different phases are reported. Transition pressure for the non-metallic phase to the metallic phase is found at 284 GPA. Phase-IV...
Effect of Thiourea Concentration on Structural, Optical and Electrical Properties of Cu2ZnSnS4 Thin Films Prepared by using Spray Pyrolysis
Thin films of Cu2ZnSnS4 (CZTS) with different molar concentrations of thiourea were prepared on glass substrates using spray pyrolysis technique. The structural, optical and electrical properties of the CZTS thin films w...