Evaluation of Antiulcer Activity of Peltophorum Pterocarpum
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 6
Abstract
Introduction: Peltophorum pterocarpum is a rich source for phenols and the wood, leaves, and flowers of the plant are used as medicinal agents in traditional medicine. Peptic ulcer is a major disease of gastrointestinal tract, affecting nearly 40 lac people each year worldwide and affects 10% of world population with different aetiologies. Peltophorum pterocarpum consists of phenols and flavonoids, tannins which have potential antioxidant and cytoprotective activity. Aim: To evaluate the antiulcer activity of methanolic extract of the leaves of Peltophorum pterocarpum (MEPP) on albino rats. Materials and Methods: The rats were divided into four groups as control, standard, test 1 (extract: 100 mg/kg) and test 2 (extract: 200 mg/kg) with six rats in each group. Gastric lesions were induced by oral administration of indomethacin (20 mg/kg) followed by pylorus ligation. Standard group of animals were treated with misoprostol and test group of animals were treated with MEPP at doses of 100 and 200 mg/kg. To determine the antiulcer activity of extract, mean ulcer index, free acidity and total acidity were evaluated. Results: Ulcer index was significantly decreased at p<0.01 in MEPP treated groups as compared to control group. Total and free acidity was significantly decreased at p<0.01 in MEPP treated groups as compared to control group. Histological analysis also supported the gastro protective effect of MEPP treated groups when compared with control groups. Conclusion: The study revealed that MEPP exhibited potential antiulcer activity and showed dose dependent antiulcer effect.
Authors and Affiliations
Bhupalam Pradeepkumar, CP Bhavyamadhuri, Y Padmanabhareddy, KV Veerabhadrappa, Gorantla Narayana, C Haranath, K Somasekharreddy, Akkiraju Sudheer
Keywords
Related Articles
- EP ID EP348431
- DOI 10.7860/JCDR/2017/26171.9998
- Views 81
- Downloads 0
To Assess Functional Outcome for Intra-Articular and Extra-Articular Distal Femur Fracture in Patients using Retrograde Nailing or Locked Compression Plating
ABSTRACT Introduction: Distal femur fractures are one of the most common fractures encountered in high velocity trauma which are associated with high morbidity and mortality. The incidence of distal femoral fractures is...
Radiological Manifestations of Pulmonary Tuberculosis - A Comparative Study between Immunocompromised and Immunocompetent Patients
Introduction: Pulmonary tuberculosis has atypical radiological manifestations in patients with underlying immunocompromised disease like diabetes and human immunodeficient virus infection. Computed tomography has importa...
Patient Reported Outcome Assessment of Periodontal Therapy: A Systematic Review
Introduction: Patient Reported Outcomes (PROs) are now regarded as a fundamental measure of therapeutic success. Patient’s opinion regarding the impact of disease and its treatment is assessed using scales such as Oral H...
IgG4-Related Disease Causing Facial and Recurrent Laryngeal Nerve Palsies: A Case Report
ABSTRACT Immunoglobulin G4-Related Disease (IgG4-RD) is a systemic fibro-inflammatory disorder. It can affect many different organs and tissues including salivary glands, orbits, retroperitoneum and many others. Neurolog...
A Difficult Case in Clinical Practice: Combined Polycythaemia Vera and Protein S Deficiency in a Patient with both Thrombotic and Bleeding Complications
ABSTRACT Polycythemia Vera (PV) is a chronic myeloproliferative disorder which is characterised by a high risk of developing arterial as well as venous thromboembolic complications like deep vein thrombosis, stroke, cort...