EVALUATION OF ANTIULCER ACTIVITY OF PROSOPIS JULIFLORA ETHANOL EXTRACT IN ETHANOL INDUCED GASTRIC ULCERATION IN RATS
Journal Title: Int J of Pharm Rev& Res - Year 2014, Vol 4, Issue 1
Abstract
There has been much interest in herbal medicines derived from the traditional knowledge of plant pharmacology for treatment of ulcer as there are fewer side effects. In the current study the plant Prosopis juliflora components have been explored as a potentially effective and safer antiulcer compound. A plant which is rich in Alkaloid, Flavonoids, Tannins, Anthraquinones and Quinon are responsible for inhibition of H+, K+ ATPase, inhibition of H. Pylori growth and antioxidant activity. Twenty four wistar rats were randomly allotted to four groups (6 animals per group) Group 1 was treated with water for Injection (10 ml/kg). Group 2 was treated with Ranitidine (50 mg/kg p.o dissolved in water for Injection). Groups 3 and 4 were treated with ethanol extract of Prosopis juliflora (250 and 500 mg/kg p.o. respectively). One hour after pre-treatment with test compounds, all animals of all the groups were treated with absolute ethanol at a dose volume of 1 ml/animal. Macroscopic examination was carried out with the hand lens and the presence of ulcer lesions was scored. The animals treated with Ranitidine (50 mg/kg), an ethanol extract of Prosopis juliflora (250 and 500 mg/kg) significantly reduced the ulcer score in comparison with ethanol induced ulcer control
Authors and Affiliations
Jagan Mohan Reddy P , Tejaswini DM , Ismail Shareef M, , Narasimha Murthy TP , Gopinath SM
Keywords
Related Articles
- EP ID EP153843
- DOI -
- Views 134
- Downloads 0
ROLE OF REGULATORY AFFAIRS IN A PHARMACEUTICAL INDUSTRY
Regulatory affairs (RA) professionals play critical roles in a pharmaceutical industry because it is concern about the healthcare product lifecycle, it provide strategic, tactical and operational direction and support fo...
IONTOPHORETIC DRUG DELIVERY: A NOVEL APPROACH THROUGH TRANSDERMAL ROUTE
The goal of delivery system is to get optimal therapeutic management. But, it still remains a challenge in the field of pharmaceuticals for delivery of ionic species and some non ionic. Several transdermal approaches hav...
A REVIEW ON ADVANCE TECHNOLOGIES FOR DEVELOPING TRANSDERMAL DRUG DELIVERY SYSTEMS TRANSDERMAL PATCHES: AN ADVANCE TECHNOLOGY FOR .TRANSDERMAL DRUG DELIVERY
Over the past decades, developing controlled drug delivery has become increasingly important in the pharmaceutical industry. Today about 74% of drugs are taken orally and are found not to be as effective as desired. To i...
DIRECT RESTORATIONS OF ANTERIOR TEETH: A REVIEW
The demand of direct restorations is increasing nowadays. Direct composite resin bonding procedures are growing in popularity as conservative and predictable restorative treatment alternatives. It not only has a good suc...
FORMULATION AND EVALUATION OF ORAL DISINTEGRATING TABLETS OF CANDESARTAN BY DIRECT COMPRESSION METHOD USING SUBLIMATING AGENTS
This research was to formulate and evaluate oral dispersible tablets (ODT) of Candesartan by direct compression technique using sublimation agents like Menthol and superdisintegrants Crospovidone, Sodium Starch Glycolate...