Evaluation of arterial stiffness in patients with coronary atherosclerosis, cardiac syndrome X and systemic lupus erythematosus (RCD code: I-3C.1)
Journal Title: Journal of Rare Cardiovascular Diseases - Year 2015, Vol 2, Issue 2
Abstract
Objectives: Arterial stiffness manifested by high pulse wave velocity (PWV) consists a risk factor of atherosclerosis and cardio-vascular complications. Systemic lupus erythematosus (SLE) is a generalized autoimmune disease in which patients’ prognosis depends contemporarily, in the corticosteroid era, mainly on the progression of premature atherosclerosis. The aim of the study was to assess arterial stiffness in patients with coronary atherosclerosis (CA), cardiac syndrome X (CSX) and SLE.Materials and methods: 44 CSX patients (28 females and 16 males; mean age 55,7; arterial hypertension in 32), 44 CA patients (19 females and 25 males; mean age 61,3; arterial hypertension in 41), 29 SLE patients (25 females and 4 males; mean age 37,4; arterial hypertension in 7), 29 control group (CG) patients. PWV was measured with use of SphygmoCor in all patients.Results: Patients with CSX had significantly lower PWV (9,63±1,69 m/s) as compared to CA patients (11,53±2,19 m/s) and significantly higher as compared to CG (8,07±1,03m/s) patients. The results of PWV in CSX and SLE patients (8,87±2,1 m/s) were similar. PWV increased with age and blood pressure in all groups. Diabetes mellitus and smoking caused PWV increase only in CA patients. Inflammatory markers didn’t influence PWV among patients with CA, CSX and SLE.Conclusions: Patients with CA have the highest arterial stiffness and significantly higher peripheral and central blood pressure. In SLE patients arterial stiffness is higher as compared to control group and similar as compared to the older CSX group. Diabetes mellitus and smoking increase arterial stiffness among CA patients. The prognostic value of PWV decrease in SLE patients should be addressed in large prospective clinical trials. JRCD 2015; 2 (2): 9–17
Authors and Affiliations
Hanna Dziedzic-Oleksy, Barbara Widlińska, Jakub Stępniewski, Agnieszka Sarnecka, Klaudia Knap, Grzegorz Kopeć, Wojciech Płazak, Piotr Podolec
Keywords
Related Articles
- EP ID EP245455
- DOI 10.20418/jrcd.vol2no2.173
- Views 91
- Downloads 0
Cardiac manifestations in a two‑generation family with Fabry disease (RCD code: III‑2B.2a)
Fabry disease (FD), which is also called angiokeratoma corporis difusum, ceramide trihexosidosis, and Anderson-Fabry disease, is an X-linked inborn error of metabolism of glycosphingolipid pathway. It is caused by the de...
A 39-year-old woman with atypical variant of Klippel-Trénaunay syndrome and progressive thromboembolic pulmonary hypertension, successfully treated by pulmonary thromboendarterectomy (RCD code: II-1A.5)
We present a case of 39-year old female with Klippel-Trenaunay syndrome (KTS) complicated by chronic thromboembolic pulmonary hypertension (CTEPH). Our patient was operated in adolescence by vascular surgeons and severe...
Eisenmenger Syndrome: Closing the Hole (RCD code: IV-2B.1)
Eisenmenger syndrome represents the extreme manifestation of pulmonary arterial hypertension associated with congenital heart defects (CHD). Adults with CHD represent an increasing population which will require managemen...
Successful reversal of advanced heart failure due to peripartum cardiomyopathy with aggressive pharmacotherapy and a continuous‑flow left ventricular assist device (RCD code: III-1B.8c)
Peripartum cardiomyopathy (PPCM) is a rare but potentially devastating complication of pregnancy. PPCM is not well understood and relatively little is known about its epidemiology and pathogenesis. However, it appears to...
Wunderlich’s syndrome associated with anticoa gulant treatment, heart failure, and post‐radiation vasculopathy
Background: Wunderlich’s syndrome (WS) is an extremely rare condition, characterised by spontaneous haemorrhage into the subcapsular, perirenal, and retroperitoneal spaces. The most common cause is renal angiomyolipoma....