Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival

Journal Title: Turkish Journal of Hematology - Year 2019, Vol 36, Issue 1

Abstract

Objective: Hematopoietic stem cell transplantation (HSCT) is a choice of treatment for malignant and non-malignant diseases. After HSCT, some complications may develop in patients. Cardiac complications are particularly important. The aim of this study was to investigate whether systolic pulmonary artery pressure (PAP) is a marker for overall survival (OS) in HSCT patients. Materials and Methods: In our study, 428 HSCT patients were evaluated. Ejection fraction (EF) and PAP values were investigated during symptom-oriented echocardiography in the pre-HSCT and post-HSCT periods. Results: Pre-HSCT EF values were similar between the groups. In patients with autologous HSCT (auto-HSCT) (PAP >25 mmHg), it was found that the 5-year mortality rate was 48.6%, while in the other group (PAP <25 mmHg) the 5-year mortality was 25.5%. There was a significant association between 5-year mortality rate and PAP level (p<0.046) in the auto-HSCT group. OS was 38% in the pre-auto-HSCT period with PAP values of >25 mmHg, while OS was 61% in the pre-auto-HSCT period with PAP values of <25 mmHg (p<0.001). We determined that there was a statistically significant difference between OS and PAP levels in patients with auto-HSCT. Five-year mortality rate and OS were not significantly different in patients undergoing allogeneic HSCT (allo-HSCT) (p>0.05). Conclusion: Our results suggest that pre-HSCT PAP value is an important risk factor for mortality and OS in patients undergoing auto-HSCT.

Authors and Affiliations

Ali Caner Özdöver, İlknur Gündeş, Melya Pelin Kırık, Handan Haydaroğlu Şahin, Murat Sucu, Mustafa Pehlivan

Keywords

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  • EP ID EP543481
  • DOI 10.4274/tjh.galenos.2018.2018.0015
  • Views 98
  • Downloads 0

How To Cite

Ali Caner Özdöver, İlknur Gündeş, Melya Pelin Kırık, Handan Haydaroğlu Şahin, Murat Sucu, Mustafa Pehlivan (2019). Evaluation of Cardiac Parameters in Bone Marrow Transplant Patients: Effect of Pulmonary Artery Pressure on Survival. Turkish Journal of Hematology, 36(1), 19-24. https://europub.co.uk./articles/-A-543481