Evaluation of Circulating Protein Biomarkers of Inflammation in COPD
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 4
Abstract
Background: Many of the systemic manifestations of Chronic Obstructive Pulmonary Disease (COPD) are mediated through increased levels of inflammatory proteins. Hence, there is much interest in the use of biomarkers of systemic inflammation in COPD, as these may have possible application in disease phenotyping, monitoring of disease progression or exacerbation and measuring the effects of therapeutic intervention. The study was undertaken to evaluate the circulating levels of C-reactive protein (CRP) and Interleukin-8 (IL-8) in patients of COPD. Methods: Plasma levels of CRP and IL8 were measured in 60 patients of COPD. CRP was estimated by immunoturbiditimetric method, while IL-8 levels were measured by commercially available ELISA kits. The results were expressed as mean ± SD and statistical comparison was done using student’s “t” test. Pearson’s coefficient was used for correlation analysis. Results: The levels of CRP and IL-8 were found to be significantly higher in patients with COPD as compared to the controls and the levels increased with the severity of the disease being significantly higher in the acute exacerbation of COPD (AECOPD) as compared to the stable COPD (CRP= 86.80±40.93, 25.67±21.69 mg/l and IL-8= 97.19±55.45, 21.28±15.89 pg/ml, respectively). A statistically significant positive correlation (r=0.86, p<0.001) was found between the levels of CRP and IL-8 in patients of COPD, while the levels correlated negatively with FEV1%. Conclusion: The results of the study suggest that circulating levels of inflammatory proteins are elevated in patients of COPD and correlate positively with the disease severity. It may be concluded that levels of CRP and IL8 could be a useful complimentary criteria to improve therapeutic and prognostic strategies for COPD.
Authors and Affiliations
Shivani Jaswal
Keywords
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