Evaluation of clinicopathological parameters and its relation with immunohistochemical expressions in breast carcinoma: A hospital based cross-sectional observational study
Journal Title: IP Journal of Diagnostic Pathology and Oncology - Year 2018, Vol 3, Issue 4
Abstract
Introduction Knowhow of HER2neu protooncogene amplification andor over expression and presence of hormone estrogen and progesterone receptors in tumour tissue is one of the most crucial checkpoints in the therapy of breast cancer The present study aimed to evaluate various clinicopathological parameters in the mastectomy specimens and to probe for any relation with its immunohistochemical expressionsMaterials and Methods Detailed clinical examination of the breast and the lump was done and presence of any axillary or cervical lymph nodes was also noted After clinical examination tumour size from the mastectomy specimen was recorded number of lymph nodes was noted The modified radical mastectomy samples after surgical removal were fixed in formalin and sent for histopathological examination where tissue processing and staining with haematoxylin eosin was done Post mastectomy grading of the malignant breast lesion was done Immunostaining of the HER2 protein Estrogen receptors ER Progesterone receptors PR was performed for all specimensResults The present study showed a significant inverse association between ER and PR expression and higher tumour grades axillary lymph node metastases and stage HER2neu overexpression is significantly associated with clinicopathlogical parameters like younger age group increased tumour size higher tumour grades and higher clinical staging Significant association was seen between tumour size and lymph node metastases implying that lymph node metastasis increases with larger tumour sizeKeywords Breast Carcinoma HER2Neu receptor Estrogen Receptor Progesterone Receptor
Authors and Affiliations
Karabi Konar, Mala Mukherjee, Arghya Bandopadhyay, Shatavisa Mukherjee, Nikhil Era
Umbilical pilonidal sinus- an unusual presentation
Umbilical Pilonidal Sinus (UPS) is a very rare form of umbilical disease. The presenting feature is usually pain and umbilical discharge. It affects active adolescent males with hairy abdomen and a deep naval. Treatment...
White sponge nevus- A rare entity
White sponge nevus (WSN) is an autosomaldominantly inherited form of mucosal leukokeratosis. It was first described by Hyde in 1909 and named by Cannon in 1935. Hence, it is also called Cannon's disease, hereditary leuko...
A clinico histopathologicalstudy of uterine cervix biopsy at tertiary care centre - 2 years study
Objective The majority of histopathological specimens from the gynaecological department includes uterine cervix biopsy A retrospective study was conducted for 2 years to evaluate the incidence and age wise distribution...
Comparison of ER, PR & HER2/neu(C-erb B2) reactivity pattern with various histomorphological patterns in patients with breast cancer
Introduction Globally carcinoma breast is the leading cause of cancer death in women Prognosis of such patients is related to a variety of Histomorphological features which includes Histological grade type tumor size and...
A rare case of malignant paraganglioma of urinary bladder
Paraganglioma are neuroendocrine tumors arising from extra adrenal sympathetic and Parasympathetic nervous system1 either from the chromaffin positive paraganglion tissue or the chromaffin negative glomus cells2 derived...