Evaluation of Cyclin D1 Expression in Aggressive and Nonaggressive Central Giant Cell Granuloma of the Jaws
Journal Title: Journal of Dentistry, Shiraz University of Medical Sciences - Year 2019, Vol 19, Issue 4
Abstract
Statement of the Problem: Central giant cell granuloma of the jaws is comprised of two types namely aggressive and nonaggressive. Controversy exists regarding the histogenesis of this lesion. Up to now, there are no reliable histologic or molecular methods to differentiate aggressive from nonaggressive central giant cell granuloma of the jaw. Moreover, because of different treatment of two groups, correct diagnosis is needed. Purpose: The purpose of this study was to evaluate and compare the expression of cyclin D1 between aggressive and nonaggressive central giant cell granulomas of the jaws. Materials and Method: This retrospective study was performed on 16 paraffin blocks of aggressive central giant cell granuloma, and 16 nonaggressive central giant cell granulomas from Shahid Beheshti Oral Pathology Department and evaluated the expression of cyclin D1 on giant cells and mononuclear cells of the lesions. T-test was used for quantitative evaluation and comparison of cyclin D1 expression between two groups. Results: Overexpression of cyclin D1 in giant cells and mononuclear cells of the lesions of both groups was apparent, but no significant statistical difference was seen. Cyclin D1 positivity was seen predominantly in the nuclei of giant cells. When a giant cell was positive, all the nuclei showed immunoreactivity. In each group mean percentage of the positive giant cells were higher than positive mononuclear cells and significant statistical difference (p= 0.000) was seen between them. Conclusion: Probably overexpression of cyclin D1 implicates in the pathogenesis of the central giant cell granulomas but it seems that this protein could not be used as a marker for identifying the clinical behavior of these lesions.
Authors and Affiliations
Saede Atarbashi Moghadam, Maedeh Ghorbanpour
Keywords
Related Articles
- EP ID EP419898
- DOI -
- Views 94
- Downloads 0
Ergonomic Evaluation of Dental Professionals as Determined by Rapid Entire Body Assessment Method in 2014
Statement of the Problem: In dentistry, incorrect working posture is the most important cause of musculoskeletal disorders. Purpose: The aim of this research was to evaluate the work postures of general dentists and spe...
The Risk Factors in Early Failure of Dental Implants: a Retrospective Study
Statement of the Problem: Despite the low failure rate of dental implants, recognition of the risk factors can enhance the predictability of failure. Purpose: The aim of this study was to evaluate the risk factors for ea...
Effect of the of Zeolite Containing Silver-Zinc Nanoparticles on the Push out Bond Strength of Mineral Trioxide Aggregate in Simulated Furcation Perforation
Statement of the Problem: Recently, zeolite has been regarded to improve the properties of dental materials such as mineral trioxide aggregate (MTA). Purpose: The aim of the present study was to evaluate the effect of i...
Salivary Chemical Factors in Relation with Oral Cancer in Smokers and Non-Smokers: a Literature Review
Squamous cell carcinoma of oral cavity is of malignant tumors, which causes cancerous complications. DNA damage, mainly because of products of oxidative stress like reactive oxygen species, is a frequent mutagenic that t...
Radiographic Evaluation of Dental Anomaly Prevalence in a Selected Iranian Population
Statement of the Problem: Many studies have explored the prevalence of dental anomalies, with conflicting results, possibly attributed to differences in the ethnicities of the populations evaluated. Purpose: The aim of...