Evaluation of Diffusion Anisotropy and Diffusion Shape in Grading of Glial Tumors
Journal Title: Journal of Biomedical Physics and Engineering - Year 2019, Vol 9, Issue 4
Abstract
Background: The most common primary tumors of brain are gliomas. Grading of tumor is vital for designing proper treatment plans. The gold standard choice to determine the grade of glial tumor is biopsy which is an invasive method. Objective: In this study, we try to investigate the role of fractional anisotropy (diffusion anisotropy) and linear anisotropy coefficient (its shape) with the aim of Diffusion Tensor imaging (as a non-invasive method) in the grading of gliomas. Methods: A group of 20 patients with histologically glial approved was evaluated. In this study, we used a 1.5-Tesla MR system (AVANTO; Siemens, Germany) with a standard head coil for scanning. Multi-directional diffusion weighted imaging (measured in 12 non-collinear directions) and T1 weighted non-enhanced were performed for all patients. We defined two Regions of Interest (ROIs); white matter adjacent to the tumor and the homologous fiber tracts to the first ROI in the contralateral hemisphere. Results: Linear anisotropy coefficient (CL), fractional anisotropy (FA) values and ratios of low-grade peri-tumoral fiber tracts were higher than high-grade gliomas (Pvalue CLt =0.014, P-value CLt/n=0.019 and P-value FAt =0.006, P-value FAt/n=0.024). In addition, we perform ROC curve for each parameter (CL ratio-AUC = 0.82 and FA ratio-AUC = 0.868). Conclusion: Our findings prove significant difference between diffusion anisotropy (FA) and diffusion shape (Cl) between low grade and high grade glioma, based on which we find this evaluation helpful in the grading of glial tumors. Citation: Davanian F, Faeghi F, Shahzadi S, Farshifar Z. Evaluation of Diffusion Anisotropy and Diffusion Shape in Grading of Glial Tumors. J Biomed Phys Eng. 2019;9(4):459-464. https://doi.org/10.31661/jbpe.v0i0.513.
Authors and Affiliations
F. Faeghi, S. Shahzadi, Z. Farshidfar
Keywords
Related Articles
- EP ID EP648053
- DOI -
- Views 95
- Downloads 0
Editorial
there is no Abstract.
A Comparison of Six Ultrasound Stimulation Types on Pseudomonas Aeruginosa Growth in Vitro
Background: This work evaluated the efficiency of common ultrasound stimulation (U.S.S) types on bacterial growth in vitro using clinically relevant conditions. Objective: To estimate different frequencies ultrasound bac...
Why Should We Have a Periodic Safety and Performance Program for Medical Devices
Nowadays, more than 10,000 different types of medical devices can be found in hospitals.These devices used in medical centers and hospitals for monitoring and treatment of patients require periodic safety and performance...
Uncertainty Analysis in MRI-based Polymer Gel Dosimetry
Background: Polymer gel dosimeters combined with magnetic resonance imaging (MRI) can be used for dose verification of advanced radiation therapy techniques. However, the uncertainty of dose map measured by gel dosimeter...
Synergistic Effects of NDRG2 Overexpression and Radiotherapy on Cell Death of Human Prostate LNCaP Cells
Background: Radiation therapy is among the most conventional cancer therapeutic modalities with effective local tumor control. However, due to the development of radio-resistance, tumor recurrence and metastasis often oc...