Evaluation of Dose Dependent Changes in Flow Rate, Ph, Total Protein and Alpha Amylase Content of Whole Saliva in Patients Undergoing Head and Neck Radiation.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 4
Abstract
Objective:The aim of the study was to estimateand evaluate the dose dependent changes in the salivary flow rate, pH, level of total protein, and αamylase during the course of radiotherapy in oropharyngeal cancer patients. Patients and method: The study group comprised of 50 patients undergoing radiotherapy for oropharyngeal carcinoma in a tertiary care centre in Chennai. Cobalt 60 equipment was used for radiation treatment. A weeklydose of 10 Gy for about 6 to 7 weeks with total dose of 60 to 66 Gy was administered. The whole saliva was collected from these patients in eppendrof sample tubes by spitting method after stimulation by a piece of paraffin wax. The salivary samples were collected prior to and during radiation treatment of 10 Gy, 40 Gy and 60 Gy.. The salivary flow rate, pHwas measured and the level of total protein and alpha amylase were estimated by using chemical diagnostic test kits. Results:The study revealed that there was 42.5% reduction in the salivary flow rate after the dose of 10 Gy, 65% reduction after the dose of 40 Gy and about 77.5% reduction after the dose of 60 Gy. there was reduction in the pH of saliva for about 0.46 units after the dose of 10 Gy, for about 0.82 units after 40 Gy and for about 1.14 unit after 60 Gy. It was found that there was reduction in the level of salivary amylase for about 36.1% after the dose of 10 Gy (after 1 week), for about 78.5% after the dose of 40 Gy (after 4 weeks) and for about 90.9% after the dose of 60 Gy.). The present study revealed that there was increase in the level of total protein for about 18.9% after 10Gy, 6.16% increase after 40Gy and 83% increase in the level after 60 Gy(6 weeks).
Authors and Affiliations
Dr. Sarala K, Dr. Bakyalakshmi K, Dr. Jayachandran S
Keywords
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- EP ID EP572691
- DOI 10.9790/0853-1804080105.
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