Evaluation of Drugs Used in the Management of Chronic Kidney Disease in a Tertiary Care Teaching Hospital
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 5
Abstract
Chronic kidney disease, a global health problem with possible complications and risk factors besides showing a remarkable negative effect in quality of life. The present study is concerned to evaluate the drugs used in management of Chronic Kidney Disease and to identify the side effects associated with treatment. A prospective observational study carried out in SVRR Govt. General Hospital during March to September 2014 (6months). A total of 65 patients were included in the study with the patient consent. A specially designed proforma was used to collect patient data. Prescriptions were evaluated and pharmacokinetic profiles of the prescribed drugs were studied. 658 drugs (27 different categories) were prescribed for 65 CKD patients. We observed 29 prescriptions with more than 10 drugs and 294 (44%) drugs were extensively excreted through kidneys. 83 drugs are contraindicated in CKD patients and 17 drugs have narrow therapeutic index. ADRs were observed in 31 (a total of 51 ADRs) prescriptions. 45% of patients experienced ADRs, which indicates the need for clinical pharmacist intervention in the treatment of CKD patients. Further studies are needed to be performed to check the health outcomes in CKD patients after implementing the intervention recommended in our study.
Authors and Affiliations
*Dr. Sahithi Sri A, Dr. Reena N, Mr. Dhanunjaya S
Keywords
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- DOI 10.9790/3008-1205016568
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