Evaluation of efficacy and tolerability of ferrous bisglycinate tablets in comparison with ferrous sulphate tablets in patients with iron deficiency anemia
Journal Title: Journal of Pharmacy Research - Year 2011, Vol 4, Issue 8
Abstract
Background: Iron deficiency anemia is the most common nutritional deficiency disorder in the world, especially in India and other developing countries. Surveys in different parts of the country reveal that 87% of pregnant women suffer from anemia and about 10% have severe anemia. Aim: The present study was carried out to evaluate the efficacy and tolerability of ferrous bisglycinate tablets in comparison with ferrous sulphate tablets in patients with iron deficiency anemia.Methods:Adult patients with iron deficiency anemia received either ferrous bisglycinate or ferrous sulphate tablet twice daily for six weeks. Clinical and laboratory evaluations were performed at the baseline, on 21 st day and at the end of treatment on day 42. Patients were also evaluated for any adverse effects occurring during the course of the study. Results: The 42-day daily treatment with ferrous bisglycinate or ferrous sulphate resulted in significant increase in haemoglobin (Hb) levels. The increase in Hb in ferrous bisglycinate group was 22.72%, which was significantly higher than the ferrous sulphate group (18.66%). The overall efficacy of the treatment assessed by both the patient and the physician was similar in both groups. At the end of the study, percentage of patients who suffered from side effects was significantly higher in ferrous sulphate group (14.6%- constipation, 14.1%- nausea) compared to ferrous bisglycinate (7.8%- constipation, 8.9%- nausea).Conclusion: Ferrous bisglycinate is a potentially valuable t
Authors and Affiliations
S a r o j S i n g h 1 , S h i k h a S i n g h 2 , Subhadra Lata 3 , Ratna Jain 4 , Uma B i s s a 5 , T. Ramanidevi 6
Keywords
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