Evaluation of expression of p16INK4a & Survivin in squamous neoplasm of cervix- A 3 years study
Journal Title: Perspectives In Medical Research - Year 2017, Vol 5, Issue 1
Abstract
Background: To explore the expression of p16INK4a(p16) & survivin in cervical intraepithelial neoplasm (CIN) & cervical squamous neoplasm Material and Methods : A 3years study was undertaken in MGM Hospital, Warangal, all the cervical & hysterectomy specimens were studied. By considering both exclusion & inclusion criteria 46 cases were taken for p16INK4A & survivin expression & data was analysed Results :The p16INK4A & survivin expressions showed the presence of statistical significance in cervical cancer, CIN1, CINII, CINIII and a normal cervical tissue & the comparison also revealed statistical significance among group. P16INK4A showed increase intensity with grade ( CINI = 28.57%, CINII = 44.44%, CINIII = 70%, & SCC = 90%), whereas survivin expressions were positive for both nuclear as well as cytoplasm staining( CINI = 28.57%, CINII = 22.22%,CINIII = 40%, SCC = 75% ) . Moreover, p16INK4A protein was associated with CIN grade & in cervical cancer; survivin protein was also related with clinical stages, CIN grade; the p16INK4A & survivin expressions were positively correlated with cervical cancer, & associated with poor prognosis of cervical cancer. Conclusion :Briefly, p16INK4A & survivin expressions were positively correlated with the clinic-pathological & prognosis of cervical cancer.P16INK4A linearly correlates well with increasing grade of CIN & SCC, whereas as survivin does not shows linear correlation with increasing grades of CIN . But it was the useful marker for differentiating CIN & SCC, especially in diagnostically difficult cases.
Authors and Affiliations
S. Lokesh Rao Magar
Keywords
Related Articles
- EP ID EP301092
- DOI -
- Views 132
- Downloads 0
Successful surgical revascularization of the congential left main coronary artery atresia in an infant
Congenital anomaly of the coronary arteries is a rare disease occurring in 1%–2% of all congenital heart diseases. Atresia of the left main coronary artery is one of its least-frequently observed variations, with very fe...
Postnatal quality of life: A neglected research area in India
World Health Organization defines Quality of Life (QOL) as “individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectation...
A Clinical Study of Surgical Site Infections in a Tertiary care Hospital
Introduction: Surgical infections are those that occur as a result of a surgical procedure or those that require surgical intervention as part of their treatment. They are characterized by a breach of mechanical/anatomic...
Antepartum fetal surveillance by non stress test and its correlation with perinatal outcome
Objective: The main objective of the study was to assess the role of NST (non stress test) in perinatal outcome in high risk pregnancy. Materials and Methods: Total 402 women with high risk pregnancy were enrolled into...
Nephro-protective effect ofPiliostigmathonningii extract on pregnant Wistar rats
Introduction: Pregnancy is a dynamic process characterized by dramatic physiological, anatomical and biochemical changes Aims and objectives : This research was aimed at investigating the effect of ethanol extract of P...