Evaluation of Genotoxic, Embryotoxic and Teratogenic Potential of Paracetamol in Humans and Mice
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 2
Abstract
Paracetamol being an over the counter drug is widely used as an analgesic. Though it was considered to be safe earlier, recent studies have shown that at high doses it does have a deleterious effect on humans as well as rodents. The present study was therefore undertaken to elucidate the genotoxic and teratogenic potential of paracetamol (acetaminophen) in the humans and in mice. The association of paracetamol intake during pregnancy and congenital malformations in the offspring was studied by epidemiological studies and by animal experimentation. The genotoxicity of paracetamol was tested by micronuclei test. Analysis of the data collected by proforma for the epidemiological study showed a higher frequency of occurrence of malformations in the offspring of the mothers who had consumed paracetamol during pregnancy (62.12%) as compared to those without paracetamol intake (48.48%). There was an increase in the micronuclei in the mice treated with paracetamol doses of both doses of 0.030 gms / Kg Bodyweight / day and 0.060 gms / Kg Bodyweight / day as was insignificant when compared to the control set. In the teratogenic study for both the paracetamol treated group of female mice, there was termination of pregnancies in the first trimester. It may therefore be assumed that paracetamol at the normal prescribed dose is not `genotoxic but it does have a embryotoxic potential in the mice
Authors and Affiliations
Dr Nandini Vaz Fernandes
Keywords
Related Articles
- EP ID EP273433
- DOI -
- Views 71
- Downloads 0
A Case of Recurrent Gastrointestinal Stromal Tumour (Gist): Case Report and Review of Literature
Gastrointestinal stromal tumors (GIST) are the most frequently encountered mesenchymal neoplasms of the gastrointestinal tract. They can also originate in the mesentery and omentum1 . Incidence wise, they are rare and ra...
Comparison of Obstructive Sleep Apnea Characteristics in Obese and NonObese Subjects by Anthropometric and Polysomnographic Data
Objective: To compare the anthropometric and polysomnographic data between obese and non-obese subjects with obstructive sleep apnea (OSA). Materials and Methods: A prospective parallel group comparative study was conduc...
Locking Vs Buttress Plating in Management of Fracture Upper End of Tibia
Introduction- Fractures of proximal tibia involves a major weight bearing joint i:e knee joint and are serious injuries that frequently result in functional impairment. To preserve normal knee function surgeon must try t...
Characteristics of Monomicrobial and Polymicrobial Ventilator Associated Pneumonia in a Tertiary Care Hospital
Background: Ventilator associated pneumonia (VAP) occurs after 48 hours in mechanically ventilated patients. They are a significant cause of morbidity and mortality. Materials and Methods: 100 patients were selected for...
Role of Water Soluble Contrast in Management of Post- Operative Adhesive Small Bowel Obstruction
This study “Role of water soluble contrast in management of post-operative small bowel obstruction” was conducted in Department of surgery N.S.C.B. medical college between August 2013 to October 2014 to assess the therap...