EVALUATION OF HEPATOPROTECTIVE ACTIVITY AND HISTOPATHOLOGICAL CHANGES IN LIVER OF ALBINO RATS TO FIND OUT THE EFFECT OF EXTRACT OF Sechium edule ROOTS AGAINST PARACETAMOL INDUCED HEPATIC DAMAGES
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2016, Vol 5, Issue 5
Abstract
The present study was conducted to evaluate the hepatoprotective activity of Ethanolic extract of Sechium edule against paracetamol induced liver damage in rats. The Ethanolic extract of Sechium edule (300mg/kg & 600mg/kg) was administered orally to the animals with hepatotoxicity induced by single dose of Paracetamol (2gm/kg). Silymarin (25mg/kg) was given as reference standard. All the test drugs were administered orally by suspending in 0.5% Carboxy methyl cellulose (CMC) solution. The Ethanolic extract of leaves of plant Sechium edule in the doses of 300mg/kg, 600mg/kg body wt, reduced the levels of serum SGPT, SGOT, ALP and Total bilirubin and increased the Total protein level significantly. In the histopathological studies of the liver section of rats showed the significant recovery with the Ethanolic extract of Sechium edule when compared with Control group and Paracetamol treated group. Keywords: Sechium edule, Paracetamol, Hepatoprotetive, Bilirubin.
Authors and Affiliations
Mr. Bapi Ray Sarkar
Keywords
Related Articles
- EP ID EP418337
- DOI -
- Views 121
- Downloads 0
Developing a Herbal Cocktail for prevention of Stroke and cerebrovascular diseases
Natural herbs have long been used in food supplements to promote health as healthy alternative to the various conditions/diseases as preventive medicine. A variety of herbs and prescriptions have been demonstrated to hav...
PHARMACEUTICO THERAPEUTICS OF SULPHUR (GANDHAKA) AN AYURVEDIC REVIEW
The term Sulfur or Sulphur derived From the Sanskrit word "Shulvari"(Shulva + Ari) meaning enemy of shulva or copper metal(Anti-copper). Sulphur occurs free in abundant quantities and hence was probably known to ancient...
Comparative study of physiochemical properties of available commercial grade Mustard oil of Bangladesh
Mustard oil, commonly used vegetable oil in Bangladesh containing low saturated fat compared to other cooking oils and enriched with essential vitamins. The purpose of the present study was to evaluate the quality of com...
Immunoprecipitation of 11 ZN fingers Domains, CTCF and BORIS to Multifunctional Y-box DNA/RNA-binding factor, YB-1 in Glioma-RGBM
CCCTC binding factor (CTCF) is a unique highly conserved and ubiquitously expressed 11 zinc finger (ZF) transcriptional factor with multiple target site. It is able to bind to various target sequences to perform differen...
Comparative Study for the Assessment of Compliance in Alcoholics and Non-Alcoholic Patients on Anti-tubercular Therapy – A Prospective Observational Study
Background: Compliance to Anti-tubercular therapy is very important for the treatment and also to prevent the relapse or failure of the treatment. Nevertheless, many people fail to adhere to the therapy and various facto...