EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SAPINDUS EMARGINATUS VAHL.PERICARP EXTRACT AGAINST ANTI TUBERCULAR DRUGS INDUCED LIVER DAMAGE IN RATS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 5
Abstract
The objectiveof the present study is to evaluate the hepato protective activity of Sapindus emarginatus Vahl. pericarp against anti tubercular drugs induced liver damage in rats. Hepatotoxicity was induced by Rifampicin and Isoniazid administration (100±50 mg/kg p.o) at every 72 hrs for 21days. Sapindus emarginatus extract at different doses (200 and 400 mg/kg) 1hr prior to Rifampicin and Isoniazid administration. The degree of protection was determined by measuring levels of biochemical markers like SGOT,SGPT,ALP and Bilirubin and anti oxidant enzymes CAT, SOD, non enzymatic anti oxidant GSH and level of lipid peroxidation .The histopathology studies also carried out. Treatment of rats with different doses of plant extract (200 and 400 mg/kg) significantly (P<0.001) altered serum marker enzymes and antioxidant levels to near normal against rifampicin and isoniazid treated rats. The activity of the extract at dose of 200 mg/kg was comparable to the standard drug, silymarin (50 mg/kg, p.o.). The present study suggests that the methanolic extract of Sapindus emarginatus posses significant hepatoprotective and anti oxidant activities.
Authors and Affiliations
Shoba Rani J, Janarthan M, Firasat Ali
Keywords
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