Evaluation of hypoglycemic activity of aqueous extract of bark of Ficus bengalensis linn. in alloxan induced diabetic rats
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2017, Vol 5, Issue 2
Abstract
Objective: Evaluation of Hypoglycemic activity of Extract of bark of Ficus bengalensis Linn. In alloxan induced diabetic albino rats and comparison with standard drug Glibenclamide. Methods: Aqueous extract of bark of Ficus bengalensis was evaluated for hypoglycemic activity. Albino rats were divided into five groups of six-animals each. Diabetes was induced by using Alloxan monohydrate (180mg/kg.b.w:i.p).control group was treated with normal saline 0.5; second group was treated with Glibenclamide 5mg/kg as a standard drug. Remaining 2 groups were treated with different doses (150 & 300mg/kg.b.w) of bark of F.bengalensis for a period of 28 days. Fasting glucose level estimated by using Glucometer on days 3, 7, 14, 21 and 28. Results: An Aqueous Extract of F.benglensis Linn. produced significant regulation of fasting blood glucose in diabetic rats. At the dose of 300mg/kg showed significant fall in blood glucose level as compared to 150mg/kg.b.w. Post-prandial reduction of blood glucose levels on day 3 after 3hrs of drug administration was significant (p value< 0.07) with bark 300mg as compared to other doses. This is however, highly significant (p value<0.0001) when compared with standard drug Glibenclamide Conclusions: Further study can be evaluated for its potential antidiabetic activity.
Authors and Affiliations
Arati Chikaraddy, Yasmeen A Maniyar
Keywords
Related Articles
- EP ID EP33441
- DOI -
- Views 321
- Downloads 0
Formulation and evaluation of mouth dissolving tablets of lamotrigine
Preparation of mouth dissolving tablets of Lamotrigine by direct compression using different concentration of superdisintegrants like Indion 414, sodium starch glycolate (Explotab) and crospovidone (polyphasdone XL).Dr...
Formulation and evaluation of diclofenac sodium S.R. tablets using Linum usitatissimum seed mucilage Matrixing
The main accusative of the present work was to develop sustained release matrix tablets of Diclofenac sodium for maintaining therapeutic blood or tissue levels of the drug for extended period of time with minimized loc...
Effect of potato presence on the chemical and rheological properties of frying oil and physical properties of produced potato chips
In this study the effect of frying times and heating times on rheological and chemical properties of frying oil were studied. Results showed that rheological properties of frying oil did not affected by frying times an...
FOOD POISONING AND ITS SAFETY PRECAUTION
Food poisoning occurs when you swallow food or water that contains bacteria, parasites, viruses, or toxins made by these germs. Most cases of food poisoning are from common bacteria such as Staphylococcus or E. coli. F...
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF AMITRIPTYLINE HYDROCHLORIDE AND CHLORDIAZEPOXIDE IN TABLET BY RP-HPLC
A simple, economic, selective, precise, and accurate Reverse Phase High Performance Liquid Chromatography method for analysis of Amitriptyline Hcl & Chlordiazepoxide in tablet dosage form was developed and validated ac...