Evaluation of Hypoglycemic Effect of Crude Extracts and Different Fractions of Stem Bark of Acacia nilotica
Journal Title: Scholars Academic Journal of Pharmacy - Year 2017, Vol 6, Issue 8
Abstract
Diabetes mellitus is a multifactorial disease which is characterized by hyperglycemia, lipoprotein abnormalities, raised basal metabolic rate, defect in reactive oxygen species scavenging enzymes and altered intermediary metabolism of major food substances. Diabetes is a major degenerative disease in the world today, affecting at least 150 million people and having complications which include hypertension, atherosclerosis and microcirculatory disorders. The crude methanolic extract of Acacia nilotica bark with different soluble partitionates were subjected to investigate for the evaluation of analgesic, hypoglycemic, CNS depressant and antidiarrheal activity on mice and thrombolytic, anthelmintic, antimicrobial, antioxidant along with cytotoxicity different in vivo experiment. Hypoglycemic activity of the plant Acacia nilotica was evaluated and the result depicted that the Methanolic crude extract, Dichloromethanefraction at a dose of 400mg/kg body weight showed significant hypoglycemic activity compared to the standard. Keywords:Hypoglycemic effect,Acacia nilotica, Crude extracts.
Authors and Affiliations
Md. Mamun- Or-Rashid, Md. Shah Amran, Muhammad Ashiqul Islam, Taniya Idris
Keywords
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