Evaluation of Immunochromatographic Test (ICT) for Sensitivity and Specificity among Children with Typhoid Fever in a Tertiary Care Hospital, Chittagong, Bangladesh
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 11
Abstract
Abstract: A cross-sectional study was carried out in the Pediatric & Medicine wards of Chittagong Medical College Hospital (CMCH), Chittagong from July 2012 to June 2013. The aim of the study was to evaluate Immunochromatographic Test (ICT) for sensitivity and specificity among children with Typhoid fever. Maintaining an inclusion criteria based on the protocol, we recruited 150 suspected cases of typhoid fever (age >6 months to 18years) who were admitted in the above mentioned hospital. In the study, we found dominating age group was 1-5 years (56.7%). Males were also dominated in sex distribution. More than a half (56.0%) of the patients came from rura areal. More than one third (33.3%) patients had tongue coating, 29(19.3%) patients had palpable liver, 11(7.3%) patients had palpable spleen and 1(0.7%) patient had caecal gurgling. Negative ICT for typhoid fever was found in 113(75.3%) patients and positive ICT for typhoid fever was found in 37(24.7%) patients. IgM was 18(12.0%), IgM+IgM were 8(5.3%) and IgG was 11(7.3%) respectively. ICT was true positive in14 cases, false positive in 23 cases, false negative in 2 and true negative in 111 cases, where blood culture considered as gold standard. Performing Immunochromatographic test (ICT), we found sensitivity 87.5%, specificity 82.8%, accuracy 83.3%, positive predictive value 37.8% and negative predictive value 98.2% for diagnosis of typhoid fever. In the conclusion, we can say that Immunochroomatographic test (ICT) can facilitate the treatment of typhoid fever patients.
Authors and Affiliations
Dr. Zabeen Choudhury, Dr. Muna Islam, Dr. A M M Minhazur Rahman
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