Evaluation of In-vivo Neuropharmacological Effect of Sarcochlamys pulcherrima Leaf Extract in Animal Model
Journal Title: European Journal of Medicinal Plants - Year 2016, Vol 11, Issue 2
Abstract
Aim: To evaluate in-vivo neuropharmacological effect of methanolic leaf extract of S. pulcherrima in animal model. Place and Duration of Study: This study was conducted in the Department of Pharmacy, Faculty of Science and Engineering, International Islamic University Chittagong, during the period between September 2013 and April 2014. Methodology: Neuropharmacological activity of crude methanolic extract of S. pulcherrima leaf was determined by using standard animal behavioral models. Such as hole cross test and open field test for exploratory activity, thiopental sodium induced sleeping times tests for sedative activity and elevated plus maze test for anxiolytic activity. Results: Methanolic leaf extract of S. pulcherrima showed a significant dose dependent suppression of exploratory activity of swiss albino mice in hole cross and open field test respectively at both dose which is 200 mg/kg and 400 mg/kg (P<0.05). In the case of thiopental sodium induced hypnosis test, methanolic leaf extract exhibited significant sedative activity at 200 mg/kg and 400 mg/kg doses respectively (P<0.05). At 400 mg/kg dose, significant anxiolytic activity was demonstrated by methanolic leaf extract of S. pulcherrima in elevated plus maze test (P<0.05). The results of this study exhibited that methanolic extract of S. pulcherrima leaf contains significant exploratory, sedative as well as medium anxiolytic activity.
Authors and Affiliations
Mohammad Nazmul Alam, Md. Jainul Abeden, Md. Rafikul Islam, Mohammed Abu Sayeed, Sudipta Chowdhury, Md. Irfan Amin Chowdury, Israt Jahan Essha, Saima Farzana Taasin
Keywords
Related Articles
- EP ID EP349606
- DOI 10.9734/EJMP/2016/21936
- Views 114
- Downloads 0
In vitro Antioxidant and Anticancer Properties of Hydroethanolic Extracts and Fractions of Ageratum conyzoides
Background: Cancer is still a major public health burden in many countries and despite the research strides made in respect of therapeutic interventions, challenges still abound in cancer treatment. Ageratum conyzoides h...
Antidiabetic Effect of the Aqueous Extract Mixture of Andrographis paniculata and Syzygium polyanthum Leaf
Aims: To study the oral glucose tolerance effects on normal rats and the antidiabetic activity of extract mixture of Andrographis paniculata and Syzygium polyanthum on alloxan-induced diabetic rats. Study Design: Seventy...
A Natural Formulation Increases Brain Resistance to Oxidative Stress
Aims: Oxidative stress is an imbalance in the pro-oxidant/antioxidant homeostasis, characterized by excess accumulation of reactive oxygen/nitrogen species (ROS/RNS) and free radicals that can be toxic for cells by initi...
Neuropharmacological Activities of Ethanolic Extract of Cola millenii Dried Leaf in Rats
Objective: The leaf of Cola millenii is used in ethnomedicine to treat several ailments including; infections, fever and pain among several other diseases in Southwest Nigeria. Preliminary report indicates that the ethan...
Cytotoxicity and Anti-microbial Activity of Aqueous Methanolic Extract of Zingiber officinale Roscoe (Zingiberacae)
Aim: The current study evaluates the cytotoxic Activity of aqueous methanolic extract from Ginger (Zingiber officinale Roscoe, Zingiberacae) against five human cancer cell lines (lung carcinoma cell line) (A549-1), Caco-...