EVALUATION OF INNOVATIVE CO-PROCESSED ADDITIVE FOR DIRECT COMPRESSION TABLETS USING ATORVASTATIN AND DIAZEPAM AS MODEL DRUGS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 2
Abstract
Objective: The aim of the present study is to prepare and evaluate a co-processed excipient from commercially available Avecil PH102 and silicon dioxide colloidal (SDC) using direct compression technique for preparation of tablets.Methods: The effect of the ratio of the two components on the properties of the prepared co-processed excipient has been investigated. In addition, it was evaluated for flowability, compressibility, and compatibility utilizing Fourier transforms Infrared (FTIR) and Differential scanning calorimetry (DSC) analysis. Tablets were produced by direct compression utilizing the co-processed additive with diazepam or atorvastatin calcium as model drugs in addition to magnesium stearate and talc as a lubricant. The addition of super disintegrant croscarmellose sodium or tablets preparation by wet granulation was utilized for comparison regarding the properties of prepared tablets. The prepared tablets were characterized for the drug content, hardness, friability, disintegration, dissolution, and stability.Results: Optimal physicochemical properties of the excipient from a manufacturing perspective were obtained using a co-processed Avecil PH102-with SDC (2% w/w) to get a mixture. The FTIR and DSC analysis showed no chemical interaction. The properties of tablets made using co-processed excipient showed good hardness, friability, acceptable tablet disintegration time, dissolution rate, and stability comparable to that obtained by the multistep method of wet granulation. Although the addition of super disintegrant more shorten the disintegration time but the obtained value without croscarmellose sodium is still satisfied the requirement.Conclusion: The Avecil PH102-SDC co-processed excipient produced was found to be promising as a valuable industrial, pharmaceutical excipient for the production of compressed tablets with good physical properties and fast dissolution.Â
Authors and Affiliations
Kahtankahtan J. Hasson, Mowafaq M. Ghareeb
Keywords
Related Articles
- EP ID EP577871
- DOI -
- Views 66
- Downloads 0
CYTOTOXIC, APOPTOTIC EFFICACY OF SILVER NANOPARTICLES SYNTHESIZED FROM INDIGOFERA ASPALATHOIDS
Objective: To study the cytotoxic & apoptotic efficacy of synthesized silver nanoparticles from I. aspalathoids against Hep3B cell line.Methods: Hep3B cell line was purchased from American type culture collection (NC...
ANTIFUNGAL ACTIVITY OF BIPHENYL-2,6-DIETHANONE DERIVATIVES
Objective: The objective of the study was to evaluate the antifungal activity of biphenyl-2,6-diethanone derivatives against Cryptococcus neoformans.Methods: Antifungal activity of biphenyl derivatives were evaluated aga...
DISCRIMINANT ANALYSIS OF PURIFICATION ON TURMERIC (CURCUMA LONGA LINN) SAMPLES BASED ON PHYTO-PHARMACOGNOSTICAL AND MULTIVARIATE CHEMOMETRIC TECHNIQUE
Objective: To establish an acceptable identification system of various purification effects in context classical based different media on turmeric samples and relates its altering pattern in favor of phyto-pharmacognosti...
SYNTHESIS, CHARACTERIZATION AND ELECTROCHEMICAL INVESTIGATION OF NOVEL 17-MEMBERED DIOXADIAZA NAPTHALDEHYDE BASED MACROCYCLIC LIGAND AND ITS COMPLEXES OF Co (III), Ni (II) AND Cu (II) PERCHLORATE IONS
Objective: The objective of this research is to synthesis hitherto, novel unreported [17]-membered dioxadiaza napthaldehyde based macrocyclic ligand (L) and to synthesize its Co(III), Ni(II) and Cu(II) metal ion complexe...
EFFECT OF ADDITIVES ON IN-VITRO RELEASE OF ORODISPERSIBLE DOSAGE FORM
Objective: The aim of this investigation was to prepare orodispersible tablets of meloxicam using various concentrations of superdisintegrants like Ac-DI-Sol, crospovidone, sodium starch glycolate by the direct compressi...