EVALUATION OF LACTATE DEHYDROGENASE- A BIOCHEMICAL MARKER OF PREECLAMPSIA
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 79
Abstract
BACKGROUND Serum LDH level is a useful predictive biochemical marker of cellular injury which reflects the severity of preeclampsia. It is a prognostic marker for both mother and foetus. Hence, its assay is useful to decide management of preeclampsia. The aim of the present study was to evaluate the LDH levels in normal pregnancy and in preeclampsia. MATERIALS AND METHODS The prospective case-control study was conducted at the Department of Obstetrics and Gynaecology, Mysore Medical College and Research Institute, Mysore. A total of 150 pregnant women were studied and divided as groups of mild preeclampsia (n=50), severe preeclampsia (n=50) and normotensive pregnant women (n=50) as control group. LDH was assayed in patients and compared with control. RESULTS Significantly higher values of serum LDH were found in mild and severe preeclamptic women when compared to normal pregnant women (p<0.0001). Also, the values of serum LDH was significantly elevated in severe preeclamptic women when comparison was done between mild and severe preeclamptic women. CONCLUSION From the present study, it can be concluded that elevated high serum LDH levels significantly correlate with the severity of preeclampsia.
Authors and Affiliations
Sushma V Dev, Hemalatha C. R
Keywords
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