Evaluation of Lepidium sativum Mucilage as Suspending Agent in Paracetamol Suspension
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2011, Vol 1, Issue 5
Abstract
Mucilages are polysaccharide complexes formed from sugar and uronic acid units. Mucilages form slimy masses in water, are typically heterogeneous in composition. The objectives of present investigation were to evaluate Lepidium sativum mucilage as a suspending agent, compare this with suspension prepared by using tragacanth as a suspending agent and marketed paracetamol suspension (Calpol 120 mg/ 5 ml), and study the effect of mucilage concentration on in vitro dissolution rate of paracetamol. Suspensions were prepared by using compound tragacanth powder and mucilage in different concentrations (1%, 1.5%, 2%, 2.5%, 3% w/v). Suspensions were evaluated for pH, sedimentation volume (F), redispersion, In vitro dissolution study and stability study. The dried and coarsely powdered seeds of Lepidium Sativum yielded high percentage (30% w/w) of dried mucilage. All formulations showed more than 80% drug release over a period of 30 minutes. The suspensions were found to be stable during the study periods. There was no any change in color, odor and taste was observed. The drug content in all the suspensions was found to be within the limit.
Authors and Affiliations
Patrakar Ramling, Sachinkumar Patil, Suchita Kamble
Keywords
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