Evaluation Of Nephroprotective Activity Of 14-Deoxy-11,12 Didehydro Andrographolidein Drug Induced Nephrotoxicity: A pilot study
Journal Title: VIMS Health Science Journal - Year 2018, Vol 5, Issue 1
Abstract
Gentamicin is a Aminoglycoside antibiotics have been used widely for the treatment of infections caused by gram-negative organisms.but eventually results in severe adverse effects namely nephrotoxicity or renal disorder through generation of reactive oxygen species (ROS). The existing drug can cure most of the disease.stil there is anever ending search for finding new drug in the hope that it would yield drug with lesser side effects and better therapeutic benefit than the existing drugs. This work was researched for evaluation of the Nephroproctive activityof 14- deoxy-11,12 Didehydro Andrographolide against gentamicin induced nephrotoxicity the 14- deoxy-11,12 Didehydro Andrographolide administered orally (10, 15,20mg/kg) for 8 day Gentamicin was administered at the dose of 7 mg/kg for 1st day intraperritoneally .Gentamicin treated group showed increased level of serum &Urine Creatinine uric acid urea ,which were significantly retrived in group pretreated with 14- deoxy-11,12 Didehydro Andrographolide .In conculsion the Histopathological & Biochemical parameter Confirmed that the 14- deoxy-11,12 Didehydro Andrographolide protect against Gentamicin induced renal damage , probably through its antioxidant activity.
Authors and Affiliations
Vikram Nimbalkar, Swapnil Jondhale, Dr. P M Gaikwad
Keywords
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