Evaluation of Oral Pregabalin Premedication for Attenuation of Pressor Response during Laryngoscopy and Endotracheal Intubation – A Randomised Clinical Study
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 12
Abstract
Background & Objective: This clinical study was designed to evaluate and compare single preoperative dose of pregabalin to placebo regarding hemodynamic responses to laryngoscopy and endotracheal intubation, to assess perioperative fentanyl requirement and any side effects. Methods: 60 ASA I and II patients undergoing elective surgical procedures were randomly selected and divided into 2 groups of 30 each. Group A received placebo and Group B received pregabalin 150mg orally 1hour before induction. The patients were compared for hemodynamic changes before the start of surgery, after induction, 1, 3, 5 & 10 minutes after intubation. Additionally fentanyl requirement during surgery and analgesia requirement during first 24 hrs of post operative period was also compared. Result: Preoperative sedation levels were higher with pregabalin premedication. Oral pregabalin significantly attenuated the heart rate(HR), systolic blood pressure(SBP),diastolic blood pressure (DBP) and mean arterial pressure( MAP) due to laryngoscopy and endotracheal intubation. Conclusion: The present study shows that single oral dose of 150mg pregabalin given 1hr before surgery attenuated the pressor response to tracheal intubation in adults, has adequately sedated the patients and was devoid of side effects in the given dose.
Authors and Affiliations
Pavan Dhulkhed
Keywords
Related Articles
- EP ID EP210068
- DOI -
- Views 51
- Downloads 0
A Study of Mineral Status in Hypothyroidism
Objective: To estimate serum calcium, phosphorus and magnesium in hypothyroidism and to compare the same in normal thyroid function. Materials and Methods: The study involved 35 controls with normal thyroid function and...
Differential Diagnosis of Alzheimer’s Disease and Other Types of Dementia with Development of Neuroimaging Techniques (PET, SPECT, and MRI)
Number of neurodegenerative diseases that cause dementia, such as Alzheimer’s disease, dementia with Lewy bodies, and front temporal dementia. In medical diagnosis many people’s cannot differentiate between Dementia and...
The Pattern of Microbial Keratitis in soft Contact Lens Wearers in a Tertiary Care Hospital in Eastern India
Background: Soft contact lenses are increasing in trend since a decade and are being used for both cosmetic and therapeutic purposes. Lack of compliance and poor hygiene towards lens care is one of the main causes associ...
An Interdisciplinary Challenge- Growing Interest on Laparoscopic Surgery during Early & Advanced Stage of Pregnancy
A literature search was performed using Medline and the search engine Google. Criteria for selection of literature were methods of analysis (statistical or non statistical), operative procedure (only universally accepted...
Urinary Iodide Excretion Studies in Thyroid Patients in North Kerala
Background: Iodine is a micronutrient for the synthesis of thyroid hormones. The decreased production of thyroid hormone results in hypothyroidism. One of the reasons for hypothyroidism is iodine deficiency. The prevalen...