Abstract

Objective: To investigate the diuretic potential of Polyherbal formulations prepared from the seeds of Vitis venifera, Duranta repens and Centratherum anthelminticum in Albino rats. Methods: Different concentrations of Polyherbal formulations (100, 200 and 400 mg/kg), furosemide (10 mg/kg) and vehicle were orally administered to rat (n = 6 animals per group) and their urine output was collected after 24h. The Urinary output, Osmolarity, pH, Na+, K+ and Cl- concentrations of urine were estimated. Results: The Polyherbal formulations produced significant increase in Na+, K+, Cl- excretion, caused alkalinization of urine, showed strong Diuretic index, saluretic index and Natruretic index. All the concentrations of Polyherbal formulation showed dosedependent relationship when compared to control animals. Conclusions: These finding strongly suggests that the Polyherbal formulations have a good diuretic activity on rats in the above experimental model.

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