Evaluation of Pre-Operative Oral Clonidine and Oral Diazepam as Pre-Medication on Extend and Duration of Sensory Blockage after Spinal Anaesthesia.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 1
Abstract
Background: Spinal anesthesia is the most common technique used for lower abdominal surgeries. Clonidine has been used as oral or intramuscular premedication to prolong the effects of spinal anesthesia with local anesthetics. Diazepam is a long acting benzodiazepine. The anxiolytic, amnesic and hypnotic effects of diazepam are the basis for the use of this drug in the pre-operative medication which is preferably accomplished with oral administration. Hence in our study we evaluated the efficacy of oral clonidine and oral diazepam as pre-medication on the extent and duration of sensory blockade in patients receiving spinal anesthesia with 0.5% bupivacaine for lower abdominal surgeries. Material And Method: In a randomized, double – blinded, control study, three groups of fourty patients each were selected. Group C received 100μg clonidine tablets, Group D received 5 mg diazepam, and group P received multivitamin tablet 90 minutes before anesthesia. Onset of sensory block, duration of sensory block, and duration of postoperative analgesia were observed along with sedation score and dryness score. Result: Postoperative analgesia was significantly longer in the clonidine group compared to the diazepam and placebo group. The mean onset time of the sensory block and the mean time to attain the maximum sensory level were significantly faster (P<0.01) in the clonidine group as compared to the diazepam and placebo group. Duration of analgesia was also significantly longer in the clonidine group compared to the diazepam and placebo group. Conclusion: We conclude that oral clonidine premedication in patients with hyperbaric bupivacaine hastens the onset of sensory block and prolongs the duration of sensory block and duration of postoperative analgesia.
Authors and Affiliations
Dr. Amol Singam
Keywords
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