EVALUATION OF RETINAL DEGENERATION IN PARKINSON’S DISEASE
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 95
Abstract
BACKGROUND Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disorder that leads to the selective loss of dopaminergic neurons which leads to axonal loss of retinal nerve fibre layer. The purpose of this study is to evaluate the progressive changes in visual acuity and retinal thickness (RNFL and macular) over 3 years in PD patients. MATERIALS AND METHODS 68 eyes of 38 idiopathic PD patients and same number of healthy controls whose sex and age were matched, underwent complete ophthalmic examination and structural analysis of the retina by SD-OCT with Cirrus HD OCT (CARL ZEISS). Both the groups were revaluated after 3 years to quantify changes in visual function parameters, retinal nerve fibre layer, and macular thickness. Progressive changes in visual acuity and retinal thickness (RNFL and macular) over 3 years were evaluated. RESULTS This current study shows patients with PD has significantly less BCVA both at baseline (0.62 ± 0.2 in PD vs. 0.52 ± 0.22 in controls) and after 3 years (0.63 ± 0.25 in PD vs. 0.54 ± 0.24 in controls) than control. Patients with PD have statistically significant RNFL thinning compared to that of controls both at baseline evaluation and after 3 years. On longitudinal followup compared to healthy controls, patients with PD had greater RNFL loss in temporal (7.55 in PD vs. 2.68 microns in controls) and superotemporal quadrants (5.47 in PD vs. 3.16 microns in controls). CONCLUSION This current study shows that in Parkinson’s disease there is RFNL thinning and macular thinning which progress faster in diseased than in control. This is also reflected in best corrected visual acuity. So we believe that RNFL thickness and macular thickness can be used in the monitoring of patient compliance and treatment effectiveness.
Authors and Affiliations
Arunava Kundu, Krishan Kanta Roy, Nazneen Nazm, Amitabha Das, Biplab Biswas, Sampurna Mukherjee, Jitendra Kumar, Yella Ramudu8 K
Keywords
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- EP ID EP280667
- DOI 10.14260/jemds/2017/1524
- Views 83
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