Evaluation of retinal nerve fiber layer and ganglion cell layer thicknesses with optical coherence tomography in patients with vitamin B12 deficiency
Journal Title: UNKNOWN - Year 2018, Vol 1, Issue 3
Abstract
Aim: We aimed to compare the retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness of B12 vitamin deficiency patients with healthy controls using optical coherence tomography (OCT). Methods: Forty-six patients (27 females / 19 males) diagnosed with B12 vitamin deficiency and 46 healthy controls (26 females / 20 males) with similar age and sex were included in the study. RNFL thickness of global, superotemporal, temporal, inferotemporal, superonasal, nasal and inferonasal sectors and GCL thickness and volume measurements of central, superior, inferior, temporal, and nasal sectors were performed using Spectralis-OCT device in all cases. Results: The mean age of the patient group was 42.17±15.34 years, while that of the control group was 44.21±12.34 years (p=0.528). Mean serum vitamin B12 levels were measured as 163,47±19,80 pg/ml in the patient group and 311,80±76,30 pg/ml in the control group (p <0,01). There was no statistically significant difference between the global RNFL thicknesses of the two groups (p> 0,05). However, statistically non-significant thinning was observed in the superotemporal and global RNFL thickness of the group with B12 vitamin deficiency (p values are 0,140 and 0,171, respectively). There was also no statistically significant difference between GCL thicknesses and volumes of the two groups (p> 0.05). Conclusions: No significant reduction was observed in RNFL and GCL thicknesses of adult subjects with B12 vitamin deficiency compared with healthy controls.
Authors and Affiliations
Umit Dogan, Sule Aydın Turkoglu, Fatih Ulas, Adem Soydan, Abdulgani Kaymaz, Tarık Eroglu, Sumeyra Agca
Keywords
Related Articles
- EP ID EP490357
- DOI 10.30714/j-ebr.2018339496
- Views 144
- Downloads 0
The relation between antiepileptic drug type and cognitive functions in childhood epilepsy: A prospective observational study
Aim: This study investigated the effect of antiepileptic drug monotherapy on cognitive functions in pediatric epilepsy patients. Methods: 98 recently diagnosed epilepsy patients aged 6-16 years were included. All pat...
Is it necessary to perform an endometrial sampling prior to hysterectomies for benign conditions?
Aim: Hysterectomy is one of the most prevalent surgical intervention in gynecological field. This study concerns the requirement and necessity of an endometrial sampling to exclude an unpredictable uterine malignancy ris...
The association of serological tests and anemia in celiac disease
Aim: Celiac disease (CD) is a common immune-mediated enteropathy caused by gluten. These patients may apply with many different clinical forms. The aim of this study is to determine the association of serolog...
Surgical treatment of inguinal hernia: Our experience
Aim: In present retrospective analysis, we aimed to evaluate the treatment results of subjects with inguinal hernia whom underwent surgical repair. Methods: Surgical treatment of inguinal hernia for last 7 years have be...
Protective effects of cordycepin on the histopathological changes and oxidative stress induced by hepatic ischemia/reperfusion in rats
Aim:To investigate the effects of cordycepin on the histopathological changes and oxidative stress induced by hepatic ischemia/reperfusion (I/R) in rats.Method: Forty male Wistar rats were randomly divided into 4 groups...