Evaluation of retinal nerve fiber layer thickness in Alzheimer’s disease using optical Coherence tomography
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 5
Abstract
Abstract: 30 diagnosed cases of Alzheimer’s disease (AD) were enrolled in this prospective study done from Apr 2015-Mar 2016.The age range of patients was 67-83 years. All subjects underwent detailed ocular examination. Average peripapillary retinal nerve fiber layer (RNFL) thickness of all patients was measured using Spectral is optical coherence tomography (OCT). These were compared with average RNFL thickness of age matched controls. There was a significant difference between RNFL thickness among two groups (p<0.05). The average RNFL thickness was found to be significantly less in patients compared to controls. Alzheimer’s disease being a neurodegenerative disorder may affect retinal ganglion cells too, reducing retinal nerve fiber layer thickness. Further, RNFL thickness may be used as a potential biological marker in diagnosis as well as progression of Alzheimer’s disease as OCT provides excellent means of keeping track of RNFL thickness. Keywords:Alzheimer’s disease, Retinal nerve fiber layer, Optical coherence tomography
Authors and Affiliations
Harshavardhan VK, Parul Priyambada, Rakesh A Betdur, S. Mohapatra
Keywords
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