Evaluation of Serum Alkaline Phosphatase and Acid Phosphatase in Relation to Abo Blood Groups and Genotypes of Male Blood Donors in University College Hospital Ibadan, Oyo State
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 1
Abstract
Background: Blood consists of plasma, erythrocytes, leucocytes and platelets. The relationship between serum levels of alkaline phosphatase (ALP), total acid phosphatase (TAP), tartrate inhibited acid phosphatase (TIAP) activities and blood groups and genotypes were studied. Methods: By standard blood grouping and electrophoretic techniques, ABO blood groups and genotypes were determined in 113 apparently healthy male blood donors who reported at University College Hospital, Ibadan (UCH). By the use of the standard methods the activities of alkaline phosphatase, total acid phosphatase, tartrate inhibited acid phosphatase were measured respectively. Standard routine tests were also used for blood grouping and blood genotypes. Participants gave their written informed consent. Results: The % distributions of ABO blood groups were: 21.2, 28.3, 8.8 and 41.6 for blood groups A, B, AB and O respectively. The % distributions of genotypes were: 70.8, 22.1 and 7.1 for genotypes AA, AS and AC respectively. The mean serum activity of alkaline phosphatase (K.A units/100ml) significantly increases in blood group 0>B>A>AB as thus: 12.72 ± 3.24, 11.05 ± 3.15, 9.41 ± 3.46, 9.21 ± 2.47 (f= 7.33; 0.000) respectively. The mean serum activity of total acid phosphatase (K.A units/100ml) significantly increases in blood group 0>AB>B>A as thus: 4.69 ± 1.39, 4.64 ± 1.02, 4.16 ± 0.91, 3.88 ± 1.15 (f= 2.96; 0.036 (P<0.05)) respectively. The mean serum activity of tartrate inhibited acid phosphatase was the same in the different blood groups studied (f= 0.81; 0.49 (P>0.05)) respectively. The mean serum activities of alkaline phosphatase, total acid phosphatase and tartrate inhibited acid phosphatase were the same in the different blood genotypes studied (f= 1.80; 0.17 (P>0.05)) respectively. There was a positive correlation between blood groups vs ALP, ALP vs TAP, ALP vs TIAP, TAP vs TIAP and a negative correlation between genotype AC and total acid phosphatase in blood donors. Conclusion: Blood group O and genotype AA has the highest prevalence rate of 41.6 % and 70.8% respectively. Blood group O has the highest levels of both serum activities of ALP and total acid phosphatase respectively while blood group A has the least levels of both serum activities of ALP and total acid phosphatase respectively.
Authors and Affiliations
I. P. Ezeugwunne
Keywords
Related Articles
- EP ID EP501715
- DOI -
- Views 47
- Downloads 0
Rescue Intubation Using a Light Wand (Trachlight) In a Case of Failed Fiberoptic Intubation in a Patient with Bleeding Oral Hemangioma
Hemangiomas of tongue are rare congenital disease associated with difficult airway and present some hazardous complication like bleeding causing airway emergency. Here we present a case report of Successful airway manage...
Pleomorphic Adenoma of the Palate: A Case Report
Pleomorphic adenoma is a benign mixed tumor composed of epithelial and myoepithelial cells arranged with various morphological patterns, demarcated from surrounding tissues by fibrous capsule. A nonulcerated mucosal swel...
The Unexplored Relationship Between Diet & Mental Health: A Review
Background: In order to understand eating behaviour of adolescents, insight into determinants of intake is necessary. Research has shown that anxiety and depression are associated with an increased risk for diabetes type...
Prevalence and Microbial Etiology of Surgical Site Infections Following Major Abdominal Gynecologic Surgeries in a Tertiary Care Center
Background and Objective- Surgical site infections (SSI) are one of the common healthcare associated infections and account for approximately a quarter of all nosocomial infections.. The risk factors and microbial etiolo...
Management of Chronic Subdural Hematoma: A Rural Institutional Experience of 98 Patients
BACKGROUND: Chronic subdural hematoma is a well known traumatic head injury in elderly patients. It has good prognosis if treated surgically in time. There are many operative interventional techniques for the treatment o...