EVALUATION OF SERUM CHOLESTEROL, AMINO TRANSFERASES, GAMMA GLUTAMYL TRANSFERASE AND CREATIVE KINASE IN RED YEAST RICE (MONACUS PURPUREUSFERMENTED RICE) FED RATS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2016, Vol 3, Issue 1
Abstract
BACKGROUND AND AIMS The purpose of this study was to determine the efficacy of red yeast rice (Monascus purpureus-fermented rice) in lowering cholesterol in the blood. At the same time, alanine aminotranferase (ALT), aspartate aminotransferase (AST) and gammaglutamyl transferase (γ-GT) were measured for notable side effects in the liver. Possible muscle damage was determined by measuring creatine kinase (CK). METHODS The cholesterol lowering effect in serum of red yeast rice-fed rats were studied over a 42-day feeding period. A total of 16 male Sprague-Dawley rats were randomised into 8 per group: control and treated. Treated rats were administered 1.35g/kg/day. Control rats were maintained on ordinary rat chow. RESULTS Serum cholesterol levels were significantly decreased by 19.13% in treated group compared to controls. This treatment also showed increase in serum ALT and AST activities by 41.90% and 21.53%, respectively. Mean CK activity in treated rats showed an increase by 32.32% when compared with control rats. γ-GT is the only enzyme that showed a decrease of 15.16% in sera of treated rats. Body weights of control and treated rats increased significantly by 10% end of feeding period but were not due to treatment. CONCLUSION Red yeast rice significantly decreased serum cholesterol level at a dosage of 1.35g/kg/day. However, the differences in serum enzyme activities between control and treated rats were not significant.
Authors and Affiliations
Anantha Babu K, Anjaly Mary Varghese
Keywords
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- EP ID EP231543
- DOI 10.18410/jebmh/2016/3
- Views 85
- Downloads 0
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