Evaluation of Serum Creatine Kinase Muscle-Brain Fraction (CK-MB) and Lactate Dehydrogenase (LDH) as Markers of Perinatal Asphyxia in Term Neonates
Journal Title: International Journal of Medical and Health Sciences - Year 2014, Vol 3, Issue 3
Abstract
Aim and Objectives: Perinatal asphyxia contributes significantly to neonatal morbidity and mortality. This study was conducted to compare the serum levels of creatine kinase muscle-brain fraction (CK-MB) and lactate dehydrogenase (LDH) among asphyxiated and non asphyxiated term neonates and to ascertain whether these enzymes can identify asphyxiated neonates who will be at high risk for hypoxic ischemic encephalopathy and multi-organ dysfunction. Material and Methods: Prospective observational study. A study was conducted on 50 neonates comprising the cases and 50 neonates comprising the controls meeting the inclusion and exclusion criteria. The blood samples for CK-MB and LDH was drawn at 8±2 and 72±2 hours of age respectively and sent for analysis. A serum CK-MB value >92.6 U/L at 8 hours and LDH value >580 U/L at 72 hours was taken as the cut-off level. Results: The cut-off CK-MB value of >92.6 U/L has 28% sensitivity with a specificity of 100%. CK-MB has a positive predictive value of 100% with a negative predictive value of 58.14%. The cut-off LDH value of >580 U/L has 59.18% sensitivity with a specificity of 92%. LDH has a positive predictive value of 87.88% with a negative predictive value of 69.70%. Conclusion: Estimation of CK-MB at 8 hours of life and LDH at 72 hours of life can help distinguish an asphyxiated from a nonasphyxiated term neonate in correlation with history and clinical features in the neonate.
Authors and Affiliations
Masaraddi Sanjay K, Sarasu M, Sulekha C, Vijayalakshmi M
Keywords
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