Evaluation of Serum Creatine Kinase Muscle-Brain Fraction (CK-MB) and Lactate Dehydrogenase (LDH) as Markers of Perinatal Asphyxia in Term Neonates at Tertiary Health Care Centre in Bikaner
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 5
Abstract
Background: Perinatal asphyxia is a common neonatal problem and contributes significantly to neonatal morbidity and mortality. Globally, hypoxia of the newborn (birth asphyxia) or the fetus ("fresh stillbirth") is estimated to account for 23% of the 4 million neonatal deaths and 26% of the 3.2 million stillbirths each year. Material and Methods: Prospective observational study. A study was conducted on 50 neonates comprising the cases and 50 neonates comprising the controls meeting the inclusion and exclusion criteria. The blood samples for CK-MB and LDH was drawn at 8±2 and 72±2 hours of age respectively and sent for analysis. A serum CK-MB value >92.6 U/L at 8 hours and LDH value >580 U/L at 72 hours was taken as the cut-off level. Results: The cut-off CK-MB value of >92.6 U/L has 28% sensitivity with a specificity of 100%. CK-MB has a positive predictive value of 100% with a negative predictive value of 58.14%. The cut-off LDH value of >580 U/L has 59.18% sensitivity with a specificity of 92%. LDH has a positive predictive value of 87.88% with a negative predictive value of 69.70%. Conclusion: Estimation of CK-MB at 8 hours of life and LDH at 72 hours of life can help distinguish an asphyxiated from a no nasphyxiated term neonate in correlation with history and clinical features in the neonate
Authors and Affiliations
Dr Kuldeep Meena
Prevalence of Anemia, Overweight and Underweight- Triple Burden among Young Women
Background: Healthy women give rise to healthy nation. Nutritional status is an important predicator of one’s health. On one hand, young women are more prone to anemia and underweight. On the other hand, overweight is al...
Study of Insulin Resistance and Metabolic Syndrome in Female Hypothyroid Patients - A Cross Sectional Study
Hypothyroidism is a common endocrine disorder in the adult population resulting from deficiency of thyroid hormone. Incidence of hypothyroidism increases with age. The prevalence of hypothyroidism is 9.3% in women and 1....
Scrub Typhus in Pregnancy: A Case Report
Scrub typhus is a rickettsial disease caused by Orientia tsutsugamushi. Clinical manifestations may vary in severity from a mild febrile illness to a fatal illness with multi organ dysfunction syndrome (MODS). Scrub typh...
Meckel Gruber Syndrome- A Case Report
This case report is about a neonate delivered at our centre, with multiple anomalies – encephalocele, micro opthalmia, flat nasal bridge, cleft lip and palate, polydactyly, ambiguous genitalia, clinically suggestive of a...
The Added Diagnostic Value of Transvaginal Ultrasound to Transabdominal Ultrasound in Detection and Assessment of Placenta Previa
Aim: To evaluate the added diagnostic value of the transvaginal ultrasound (TVUS) to transabdominal ultrasound (TAUS) in the detection and evaluation of placenta praevia (PP). Methods: This study was carried out on 46 pr...