Evaluation of Serum Interleukin 6 in Type II Diabetes Mellitus
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 1
Abstract
Background: Interleukin-6 (IL-6) suppresses insulin-dependent insulin receptor autophosphorylation, interfering with insulin sensitivity and were found to be associated with an elevated diabetes risk. The aim of the study was to estimate the serum levels of IL-6 in patients with diabetes mellitus and to compare the findings with normal individuals. Methods: Cross-sectional study. 40 cases of Diabetes Mellitus who attended Medicine OPD or admitted in the medical ward irrespective of sex, age and socioeconomic status form the study group. A group of 40 normal healthy individuals of comparable age and sex who were free of any systemic disease form the control group. Interleukin-6: IL-6 was estimated by human IL-6 ELISA kit manufactured by Krishgen Biosystems, Mumbai. IL-6 was measured by enzyme linked immunosorbent assay (ELISA) using ELISA reader as described by Helle M et al. Results: Among DM cases males have slightly higher IL-6 level (11.15 ± 1.07 pg/ml) compared to females (9.63 ± 0.41 pg/ml). Among controls also males (7.84 ± 0.29 pg/ml) have more level compared to females (7.07 ± 0.46 pg/ml). Difference between IL-6 (mean ± SD) levels among males of both groups is statistically significant and among females of both the groups is also statistically significant (p < 0.001). Conclusions: The results of this study confirm the association of the serum Interleukin-6 with Diabetes mellitus. Thus it can be concluded that estimation of serum IL-6 level may be used as a biomarker for diagnosis and prognosis of Diabetes Mellitus and may provide a useful tool for its management.
Authors and Affiliations
Victoria Laishram, Suman Debnath, Davina Hijam, Tina Das, Sneha Saha
Keywords
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- EP ID EP542277
- DOI 10.21276/ijmrp.2017.3.1.030
- Views 75
- Downloads 0
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