Evaluation of serum iron and ferritin in different treatment regimens for chronic hepatitis C virus
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 4
Abstract
This work aims to develop a biochemical study on the effect of both interferon containing treatment regimens and interferon free regimens on serum iron and serum ferritin in patients with chronic hepatitis C and to evaluate the role of iron in the severity and course of disease. Blood samples from one hundred fifty patients aged from 25 to 57 years old were withdrawn; of them 30 blood samples were positive for HCV antibodies and negative for HCV RNA (control group I) and 120 blood samples were positive for HCV antibodies and positive for HCV RNA (diseased group II) which is subdivided into four groups according to the received treatment; interferon and ribavirin (group IIa), interferon, sofosbuvir and ribavirin (group IIb), sofosbuvir and ribavirin (group IIc) and herbal therapy (group IId). After treatment there was an extremely significant decrease in iron levels (94 ± 16.96 µg/dL) in group IIa, , while there was an extremely significant increase in iron levels after treatment in group IIb and group IIc (160.4 ± 37.53 µg/dL and 183.7 ± 37.36 µg/dL), respectively. Group IId showed a non significant decrease in iron levels after treatment (150.5 ± 21.35 µg/dL). For ferritin levels, group IIa, group IIb and group IIc showed significant increase in serum ferritin levels after treatment (157.6 ± 13.44, 99.5 ±14.99, and 96.63 ± 15.22 ng/mL), respectively. On the other hand, group IId showed a non significant increase in ferritin levels after treatment (90.93 ± 6.883 ng/mL). It can be concluded that serum ferritin increases in HCV patients treated with combined pegylated interferon--alfa (PEG-IFN)-ribavirin than the other treatment regimens. In addition, Serum iron decreases in HCV patients treated with combined PEG-IFNribavirin, while serum iron increases in sofosbuvir dual and trible therapy.
Authors and Affiliations
Fagr B. Bazeed, Elsherbeny H. Elsayed, Amani A. Abd El-Aziz2
Keywords
Related Articles
- EP ID EP385014
- DOI 10.9790/3008-1104011319
- Views 115
- Downloads 0
A Simple Procedure for Comparative GC-MS Analysis of Lavender (Lavandula Angustifolia Mill.) Flower Volatile Composition.
The efficient lavender (Lavandula angustifolia Mill.) breeding for essential oil production requires routine and accurate comparison the flower volatile composition of larger number individual plants from genetic resourc...
Evaluation of saliva as a biochemical indicator for electrolyte estimation in sickle cell anaemic patientsaq
Background: Sickle cell anaemia, a type of haemoglobinopathy is associated with biochemical abnormalities such as imbalance of electrolytes. Aim: To determine and evaluate saliva as a biochemical indicator for electrolyt...
Proposal of Employ of Niacin at Massive dosage for Topical Use in Male Weak Penis erection
Recent studies demonstrate that prior application of an emulsion containing niacin as vasodilator favours subsequent luminous treatments. Aims of my research is to demonstrate that niacin administered topically at strong...
Abortifacient Potential Effect of Aqueous Extract of Millittiaaboensis on Reproductive Health of Matured Wistar Rats
The present study evaluated the abortifacient potential of aqueous extract of Millittiaaboensis on reproductive health of matured Wistar rats by assessing some fertility indices, hormonal profile and litter size of pregn...
Ethnobotanical Importance Of Zingiber In The Imphal Valley District, Manipur With Zingiber Chrysanthum Roscoe as A New Record For Manipur.
The Zingiberaceae is rich in species used as traditional medicines or spices, but extensive information about their chemistry and pharmacology is available for ginger ( Zingiber officinale). Throughout the history of for...