Evaluation of serum vitamin D levels in patients with lichen planus
Journal Title: Turkderm-Turkish Archives of Dermatology and Venereology - Year 2020, Vol 54, Issue 4
Abstract
Background and Design: Lichen planus (LP) is a chronic inflammatory disease of unknown etiology that most commonly affects the skin and oral mucosa. Vitamin D is a steroid hormone with immunomodulatory, anti-inflammatory and antioxidant effects. The purpose of this study was to evaluate serum vitamin D levels in patients with LP and to compare these with those of healthy control subjects. Materials and Methods: Forty-eight patients with a diagnosis of LP and 46 healthy controls were enrolled in the study. The serum levels of 25-hydroxy vitamin D, calcium, phosphate and parathyroid hormone were studied from blood samples collected from all subjects. Results: The serum levels of vitamin D were lower in the LP patients compared to the controls and in the oral erosive LP patients compared to the other LP patients, although the difference was not statistically significant. There were no statistically significant differences in other laboratory parameters between the patient and the control groups. Conclusion: Our study revealed no clear relation between LP and vitamin D levels. The results of our study suggest that other factors except vitamin D, particularly probable triggers, play a more dominant role in the immunopathogenesis of LP. Further studies with larger patient populations assessing serum vitamin D levels in different types of LP and vitamin D-related gene polymorphisms are now needed in order to reveal the relation between LP and Vitamin D more clearly.
Authors and Affiliations
Deniz Aksu Arıca, Leyla Baykal Selçuk, Asım Örem*, Zeynep Karaca Ural, Savaş Yaylı, Sevgi Bahadır
Keywords
Related Articles
- EP ID EP691624
- DOI 10.4274/turkderm.galenos.2020.66664
- Views 129
- Downloads 0
The efficacy of omalizumab therapy in chronic spontaneous urticaria: A retrospective analysis
Background and Design: Omalizumab is recombinant humanized monoclonal antibody that binds to immunoglobulin E (IgE). It inhibits the activation of IgE by binding to the effector cell, thereby inhibiting the release of ce...
A case of sarcoidosis diagnosed via skin involvement
Abstract(s)*
Acute generalized exanthematous pustulosis caused by a probable spider bite: A case report and review of the literature
Acute generalized exanthematous pustulosis (AGEP) is a toxic cutaneous reaction pattern that is mostly caused by drug intake and rarely associated with spider bites. We report a case of a female patient, 47 years old, wi...
Pigmented Bowen’s disease (Bowenoid Papulosis) dermoscopically mimicking melanoma
Pigmented Bowen’s disease (PBD) is a rare variant of Bowen's disease. It is important to distinguish PBD from other pigmented skin lesions such as solar lentigo, pigmented actinic keratosis, keratoacanthoma, seborrheic k...
Does counseling have an effect on sun protection behaviors and early detection of skin cancer in middle-aged and older Turkish people?
Background and Design: The most important avoidable risk factor for skin cancer is ultraviolet light exposure. The aim of this study is to evaluate the frequency and the effect of counseling on sun protection behaviors a...