Evaluation of Sperm DNA Fragmentation Index (DFI) for the Outcome of Assisted Reproductive Technique in Infertile Male

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Evaluation of Sperm DNA Fragmentation Index (DFI) for the Outcome of Assisted Reproductive Technique in Infertile Male

Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 12

Abstract

Background: The objective of this study was to determine whether there is any possible relationship between DFI with Assisted Reproductive Technique outcome and also with age and semen parameters. Methods: This was a case study of limited number of patients .15 male infertile patients undergoing ICSI were included in the present study. SCSA and ART were performed on semen aliquots taken from the same ejaculate. Semen parameters (count & morphology), Fertilization rate, Embryo quality and Biochemical pregnancy rates were also correlated to SCSA (DFI) parameter. Statistical analysis was also performed using SPSS version. Results: Significant difference was observed between the DFI of the subject and normality at a significant level of 1% (p= 0.000).The results showed no correlation between DFI and fertilization rates, biochemical pregnancy. But a weak correlation was observed between DFI and embryo quality and embryo quality with fertilization rate, biochemical pregnancy. For IUI, the DFI above 25% resulted in negative pregnancy. One ongoing pregnancy was achieved for ICSI with DFI levels 34.33%. Conclusion: DFI can be used as an independent predictor of pregnancy in case of IUI. SCSA test can be considered as accessory to the standard semen analysis in infertile men. In ART, pregnancy loss and time spending can be avoided based on SCSA (DFI) and move on to ICSI for better result.

Authors and Affiliations

Sahini. C. K

Keywords

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EP ID EP208061
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