Evaluation of Squamous Cell Carcinoma Antigen Value in Stadium IIB– IIIB Squamous Cell Cervical Cancer Patients which Receiving Bleomycin, Oncovin®, Mitomycin, and Cisplatin Chemotherapy
Journal Title: Indonesian Journal of Clinical Pharmacy - Year 2015, Vol 4, Issue 2
Abstract
Bleomycin, Oncovin®, mitomycin, and cisplatin (BOMP) chemotherapy is one of the management of cervical cancer therapy. The aim of this study was to evaluate the response to BOMP chemotherapy regimens in patients squamous cell cervical cancer stage IIB-IIIB using SCC antigen. In this prospective cross sectional study was obtained 12 cervical cancer patients who met the inclusion criteria, which is taken by using consecutive sampling method. Examination of SCC antigen levels was conducted by taking a patient’s blood before the first series and after the third series of BOMP chemotherapy, then further examined by ARCHITECT SCC assay. Data were analyzed using paired test with 95% confidence intervals. Statistical analysis showed that there were a decrease in the average value of SCC antigen in patients with squamous cell cervical cancer types after 3 series of BOMP chemotherapy although this reduction was not statistically significant (p>0.05). The differences are not statistically significant is probably due to insufficient number of patients used in this study. The doctor may consider to continue chemotherapy until the sixth series in accordance with the procedures by routine monitoring of the patient’s condition, especially SCC antigen values for predicting the prognosis and response of chemotherapy.
Authors and Affiliations
Rini Noviyani, Ketut Suwiyoga, Intan Puspa, Nyoman Budiana
Keywords
Related Articles
- EP ID EP355544
- DOI 10.15416/ijcp.2015.4.2.106
- Views 72
- Downloads 0
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