Evaluation of systemic effects of ginger fractions on salivation in rats
Journal Title: International Journal of Medical Research & Health Sciences (IJMRHS) - Year 2016, Vol 5, Issue 8
Abstract
Various herbal drugs and treatment modalities claim to stimulate salivary flow. Since the effect of ginger on increasing salivation and cholinergic activity has been shown in previous studies, we decided to evaluate the systemic effects of ginger extracts on salivation. The extracts of ginger fractions (Petroleum ether, Diethyl ether, Dichloromethane, Chloroform, Ethyl acetate, Methanol, Watery) and Total methanolic extract of ginger were prepared. In this experimental investigation ten groups of rats for seven types of ginger fractions, total ginger extract and negative and positive control groups were studied (n=7 for each group). Saliva volumes were measured gravimetrically after intraperitoneal (I.p.)injection of extracts during four continuous seven minute intervals. Systemic injection of ginger extract and each of the seven fractions did not result in an increase in saliva secretion. After injection of six extracts (Petroleum ether, Dichloromethane, Chloroform, Ethylacetate, Methanol, Watery) a significant decrease in the saliva secretion occurred (P<0.05). A decrease in salivation may be explained by dual activity of ginger (cholinergic and calcium antagonist). Use of different doses of ginger extracts (especially aqueous extract) or other preparations of ginger may be helpful for future studies on the effects of ginger on salivation.
Authors and Affiliations
Goli Chamani| Associate Professor, Department of Oral Medicine, Faculty of Dentistry, Kerman University of Medical Sciences, Kerman, Iran, Mohammad Shooriabi| Assistant Professor, Department of Oral Medicine, Faculty of Dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Corresponding Email: dsshoriabii@yahoo.com, Mohammad Reza Zarei| Associate Professor, Department of Oral Medicine, Faculty of Dentistry, Kerman University of Medical Sciences, Kerman, Iran, Mitra Mehrabani| Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran, Yaser Masoumi-Ardakani| Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
Keywords
Related Articles
- EP ID EP11906
- DOI -
- Views 259
- Downloads 10
THE DIAGNOSTIC UTILITY OF CELL BLOCK AS AN ADJUNCT TO CYTOLOGICAL SMEARS
Objectives: Cytological examination of serous fluids is of paramount importance in detecting cancer cells. Distinguishing malignant cells from benign reactive mesothelial cells in fluid cytology is an everyday diagnosti...
Nursing students’ experiences of the process of learning during clinical courses in Iran
Learning process is the result of interactions between the learners and the learning environment and paying attention to its effective factors could lead it toward achieving the expected results. This study was aimed to...
A RARE CASE OF NEUROLIPOMA
A painful swelling over the left ankle joint was excised. Histopathology revealed it to be a neuroliploma. This case is reported here for its uncommon site that is involvement peroneal nerve, no association with skelet...
COMPARATIVE STUDY ON TEACHING OF BIOETHICS TO HEALTH CARE PERSONS USING DIFFERENT METHODOLOGIES
Introduction: Bioethics has gained lots of importance in the present days and especially very important in the field of medical research. Doctors, medical students, nursing staff and other paramedical staff are directly...
MORPHOMETRIC STUDY OF THE SACRAL HIATUS IN NIGERIAN DRY HUMAN SACRAL BONES
Background: The sacrum is a large triangular bone formed by the fusion of the five sacral vertebrae and forms the caudal region of the vertebral column. Aims: This was aimed at studying the morphometry of the sacral hia...