Evaluation of The Diagnostic Role of Non-Coding RNA and Exosomal Related Gene Association in Lung Cancer
Journal Title: The Egyptian Journal of Hospital Medicine - Year 2018, Vol 72, Issue 3
Abstract
<span>Background: </span><span>Exosomes are microvesicles that are recently discovered in intercellular communication especially between tumor cells as lung cancer that are important for tumor development and progression. </span><span>Objectives: </span><span>Examine the diagnostic role of serum exosomal LncRNA in lung cancer among Egyptian population.<br /> </span><span>Methods: </span><span>Lung cancer characteristic exosomal RNA-based biomarker Lnc-RNA-RP11-510M2.10 was selected based on bioinformatic methods, followed by RT-qPCR validation of their expression in serum of 20 patients with lung cancer and 10 healthy volunteers.<br /> </span><span>Results: </span><span>serum exosomal Lnc-RNA-RP11-510M2.10 showed a significant negative association with lung cancer patients in comparison to patients with healthy persons (p<0.001).<br /> </span><span>Conclusion: </span><span>Lnc-RNA-RP11-510M2.10 could be used as diagnostic and prognostic biomarker tools for lung cancer.<br /> </span>
Authors and Affiliations
Eman Helal
Keywords
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- EP ID EP584102
- DOI 10.21608/ejhm.2018.9131
- Views 105
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